{"id":6142,"date":"2019-09-20T12:04:49","date_gmt":"2019-09-20T04:04:49","guid":{"rendered":"http:\/\/www.nikyang.com\/?p=6142"},"modified":"2021-08-25T11:24:24","modified_gmt":"2021-08-25T03:24:24","slug":"dms-health-china","status":"publish","type":"post","link":"https:\/\/www.nikyang.com\/news\/dms-health-china\/","title":{"rendered":"\u4e3a\u54cd\u5e94 \u201c\u5065\u5eb7\u4e2d\u56fd\u201d \u7684\u53f7\u53ec\uff0c\u529b\u626c DMS \u65b9\u6848\u9f0e\u529b\u76f8\u52a9\uff01"},"content":{"rendered":"\t\t
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\u524d\u6bb5\u65f6\u95f4\uff0c\u56fd\u52a1\u9662\u5370\u53d1\u4e86 \u300a\u56fd\u52a1\u9662\u5173\u4e8e\u5b9e\u65bd\u5065\u5eb7\u4e2d\u56fd\u884c\u52a8\u7684\u610f\u89c1\u300b \u4e00\u6587\uff0c\u7740\u91cd\u660e\u786e\u4e86 \u201c\u5168\u65b9\u4f4d\u5e72\u9884\u5065\u5eb7\u56e0\u7d20<\/strong>\u201d\u3001\u201c\u7ef4\u62a4\u751f\u547d\u5468\u671f\u5065\u5eb7<\/strong>\u201d \u53ca \u201c\u52a0\u5f3a\u91cd\u5927\u75be\u75c5\u9632\u63a7<\/strong>\u201d \u4e09\u4e2a\u65b9\u9762\u7684\u4e13\u9879\u884c\u52a8\uff0c\u529b\u6c42\u53ca\u65f6\u660e\u786e\u75be\u75c5\u539f\u56e0\u4ee5\u63a7\u5236\u75c5\u60c5\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u4ece\u56fd\u52a1\u9662\u53d1\u5e03\u7684\u4e00\u6587\u4e2d\uff0c\u6211\u4eec\u4e0d\u96be\u53d1\u73b0 \u201c\u7cbe\u51c6\u4e86\u89e3\u5065\u5eb7\u95ee\u9898\u201d \u7684\u91cd\u8981\u6027\u3002\u7279\u522b\u662f\u8fd1\u5e74\u6765\uff0c\u6211\u56fd\u75be\u75c5\u8c31\u66f4\u662f\u4e0d\u65ad\u53d8\u5316\uff0c\u9700\u8981\u505a\u597d\u75c5\u60c5\u76d1\u6d4b\uff0c\u624d\u80fd\u53ca\u65f6\u5730\u53d1\u73b0\u95ee\u9898\u5e76\u505a\u597d\u9884\u9632\u63aa\u65bd\u3002<\/p>

\u4eba\u4f53\u6f5c\u5728\u7684\u75be\u75c5\u662f\u5f02\u5e38\u7e41\u591a\u7684\uff0c\u540c\u65f6\u5bf9\u5065\u5eb7\u4e5f\u5b58\u5728\u7740\u6781\u5927\u7684\u5a01\u80c1\uff0c\u4e3e\u4e2a\u4f8b\u5b50, \u8fd1\u671f\u5927\u5bb6\u5bf9\u81ea\u8eab\u7684\u7ef4\u751f\u7d20 D \u90fd\u975e\u5e38\u5173\u6ce8, \u56e0\u4e3a\u7f3a\u4e4f\u5b83\u6709\u53ef\u80fd\u9020\u6210\u591a\u79cd\u9aa8\u9abc\u75be\u75c5\uff0c\u5982\u8425\u517b\u6027\u4f5d\u507b\u75c5\u3001\u8f6f\u9aa8\u75c5\u3001\u9aa8\u8d28\u758f\u677e\uff1b\u7ef4\u751f\u7d20 D \u7f3a\u4e4f\u8fd8\u4e0e\u591a\u79cd\u9aa8\u9abc\u5916\u75be\u75c5\u5bc6\u5207\u76f8\u5173\uff0c\u5982\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u80a5\u80d6\u3001\u7cd6\u5c3f\u75c5\u3001\u6076\u6027\u80bf\u7624\u3001\u611f\u67d3\u3001\u8fc7\u654f\u6027\u75be\u75c5\u53ca\u54ee\u5598\u3001\u7cbe\u795e\u53ca\u795e\u7ecf\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u6162\u6027\u80be\u75c5\u7b49\u3002[1]<\/sup><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\uff08\u56fe\u7247\u6e90\u4e8e\u7f51\u7edc\uff09<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u7ef4\u751f\u7d20\u00a0<\/strong>D (Vitamin D) <\/strong>\u4e3a\u4eba\u4f53\u5fc5\u9700\u7684\u4e00\u79cd\u8102\u6eb6\u6027\u7ef4\u751f\u7d20\uff0c\u5bf9\u7ef4\u6301\u4eba\u4f53\u9499\u7684\u52a8\u6001\u5e73\u8861\u65b9\u9762\u8d77\u7740\u975e\u5e38\u91cd\u8981\u7684\u4f5c\u7528\u3002\u4e3a\u6b64\uff0c\u8bb8\u591a\u7814\u7a76\u4eba\u5458\u5bf9\u7ef4\u751f\u7d20 D \u7f3a\u4e4f\u75c7\u7684\u5174\u8da3\u9010\u6e10\u589e\u52a0\u3002\u636e 1997 \u5e74\u516c\u5e03\u7ef4\u751f\u7d20 D \u7684\u53c2\u8003\u6444\u5165\uff0c\u8840\u6e05 25 \u7f9f\u57fa\u7ef4\u751f\u7d20 D [25(OH)D] \u88ab\u5b9a\u4e49\u4e3a\u53cd\u6620\u4eba\u4f53\u5185\u7ef4\u751f\u7d20 D \u72b6\u6001\u7684\u6700\u4f73\u6307\u6807\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u76ee\u524d\uff0c\u53ef\u7528\u4e8e\u6d4b\u91cf 25(OH)D \u6709\u591a\u79cd\u65b9\u6848\uff0c\u5982\u9176\u8054\u514d\u75ab\u6cd5\u3001\u653e\u5c04\u514d\u75ab\u6280\u672f\u7b49\uff0c\u8f83\u4e3a\u5148\u8fdb\u7684\u6280\u672f\u662f\u6db2\u76f8\u8272\u8c31\u4e32\u8054\u8d28\u8c31\u6280\u672f (LC-MS\/MS)\uff0c\u5177\u6709\u9ad8\u7279\u5f02\u6027\u3001\u9ad8\u9009\u62e9\u6027\u3001\u9ad8\u7075\u654f\u5ea6\u3001\u68c0\u6d4b\u5feb\u901f\u7b49\u72ec\u7279\u4f18\u52bf\uff0cLC-MS\/MS \u4ea6\u5df2\u88ab\u7f8e\u56fd\u56fd\u5bb6\u6807\u51c6\u6280\u672f\u7814\u7a76\u6240 (NIST) \u8a89\u4e3a\u89c4\u8303\u5316\u6d4b\u91cf 25(OH)D \u7684 \u201c\u91d1\u6807\u51c6\uff02[<\/sup>\uff12<\/sup>]<\/sup>\u3002<\/p>

\u4f46\u5bf9\u4e8e 25(OH)D \u6d4b\u91cf\u7684\u96be\u70b9\u5728\u4e8e\u6837\u54c1\u524d\u5904\u7406<\/strong> (<\/strong>Sample Preparation)<\/strong>\uff0c\u5176\u539f\u56e0\u5728\u4e8e\u8840\u6db2\u6837\u54c1\u57fa\u8d28\u7684\u590d\u6742\u6027\uff0c\u73b0\u6709\u7684\u65b9\u6cd5\u9700\u8981\u505a\u884d\u751f\u5316\uff0c\u4e0d\u4ec5\u6b65\u9aa4\u7e41\u7410\uff0c\u800c\u4e14\u6210\u672c\u9ad8\u3002\u968f\u7740\u6d4b\u91cf\u9700\u6c42\u65e5\u76ca\u589e\u591a\uff0c\u6837\u54c1\u524d\u5904\u7406\u5de5\u4f5c\u5360\u7528\u4e86\u5927\u91cf\u4eba\u529b\uff0c\u6210\u4e3a\u5236\u7ea6\u4e34\u5e8a LC-MS \/ MS \u5206\u6790\u7684\u6700\u5927\u74f6\u9888\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\"\u5b9e\u9a8c\u5ba4\u6837\u54c1\u5904\u7406\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u9488\u5bf9\u7ef4\u751f\u7d20 D \u68c0\u6d4b\u7684\u6311\u6218\uff0c\u529b\u626c\u4f01\u4e1a\u5f15\u8fdb\u4e86\u4e00\u79cd\u66f4\u52a0\u4fbf\u6377\u7684\u68c0\u6d4b\u65b9\u5f0f \u2014\u2014 \u5e72\u57fa\u8d28\u70b9<\/strong><\/span> (DMS, Dried Matrix Spot) <\/strong><\/span>\u8403<\/strong><\/span>\u53d6\u6280\u672f<\/strong><\/span>\uff0c\u5e2e\u52a9\u5e7f\u5927\u7fa4\u4f17\u63d0\u4f9b\u7cbe\u51c6\u7684\u7ef4\u751f\u7d20\u8425\u517b\u68c0\u6d4b\uff0c\u540c\u65f6\u66f4\u54cd\u5e94\u4e86\u56fd\u52a1\u9662 \u201c\u5065\u5eb7\u4e2d\u56fd\u201d \u7684\u53f7\u53ec\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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DMS \u8403\u53d6\u6280\u672f<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u53ea\u9700\u91c7\u96c6\u5fae\u91cf\u7684\u6db2\u4f53\u6837\u54c1\u4fbf\u53ef\u8fdb\u884c\u5168\u9762\u3001\u7cbe\u51c6\u7684\u68c0\u6d4b\uff0c\u540c\u65f6\u6837\u54c1\u4e0d\u5c40\u9650\u4e8e\u8840\u6db2\uff0c\u8fd8\u80fd\u91c7\u96c6\u5c3f\u6db2\u3001\u553e\u6db2\u7b49\u4f53\u6db2\u3002\u68c0\u6d4b\u8fc7\u7a0b\u5341\u5206\u7b80\u5355\uff1a\u5c06\u6db2\u4f53\u6837\u672c\u6ef4\u5728\u91c7\u96c6\u5361\u4e0a\uff0c\u7136\u540e\u901a\u8fc7\u529b\u626c\u63d0\u4f9b\u7684\u745e\u58eb CAMAG \u5168\u81ea\u52a8\u5e72\u8840\u6591\u63d0\u53d6\u7cfb\u7edf (DBS-MS 500\uff09\uff0c\u81ea\u52a8\u4ece\u91c7\u96c6\u5361\u63d0\u53d6\u6837\u672c\uff0c\u5e76\u53ef\u4ee5\u76f4\u63a5\u8fde\u63a5\u5230\u6db2\u76f8\u8272\u8c31-\u4e32\u8054\u8d28\u8c31\u4eea (LC-MS\/MS) \u8fdb\u884c\u5206\u6790\u3002\u8be5\u6280\u672f\u4e0d\u4f46\u4fdd\u8bc1\u4e86\u68c0\u6d4b\u7684\u51c6\u786e\u6027\uff0c\u4e5f\u7b26\u5408\u5065\u5eb7\u4e2d\u56fd \u201c\u7cbe\u51c6\u4e86\u89e3\u5065\u5eb7\u95ee\u9898\u201d \u7684\u9700\u6c42\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u7efc\u5408\u6765\u8bf4\uff0cDMS <\/strong>\u8403\u53d6\u6280\u672f\u4e0d\u4ec5\u64cd\u4f5c\u7b80\u5355\uff0c\u66f4\u5177\u6709\u4ee5\u4e0b\u7279\u70b9\uff1a<\/p>

  1. DMS \u91c7\u6837\u6280\u672f\u5177\u5907\u91c7\u6837\u65b9\u4fbf\uff08\u60a3\u8005\u53ef\u81ea\u884c\u91c7\u96c6\uff09\u3001\u5fae\u91cf\u4f4e\u521b\u3001\u5ba4\u6e29\u8fd0\u8f93\u50a8\u5b58\u548c\u4f4e\u751f\u7269\u5371\u5bb3\u6027\u7b49\u4f18\u52bf\uff1b<\/li>
  2. \u6837\u54c1\u8403\u53d6\u8fc7\u7a0b\u5168\u9762\u81ea\u52a8\u5316\uff0c\u51cf\u5c11\u7531\u4e8e\u624b\u5de5\u64cd\u4f5c\u5e26\u6765\u7684\u8bef\u5dee\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8\u4e86\u68c0\u6d4b\u7ed3\u679c\u7684\u51c6\u786e\u6027\u548c\u518d\u73b0\u6027\uff0c\u5b9e\u73b0\u201c\u7cbe\u51c6\u68c0\u6d4b\u201d\uff1b<\/li>
  3. \u5927\u5e45\u5ea6\u964d\u4f4e\u533b\u62a4\u4eba\u5458\u7684\u5de5\u4f5c\u538b\u529b\uff0c\u4ec5\u9700\u6781\u77ed\u7684\u65f6\u95f4\u4fbf\u53ef\u5f97\u5230\u7cbe\u786e\u7684\u68c0\u6d4b\u7ed3\u679c\uff0c\u53ca\u65f6\u4e3a\u60a3\u8005\u63d0\u4f9b\u7cbe\u51c6\u7684\u6cbb\u7597\u65b9\u6848\uff0c\u6700\u5927\u7a0b\u5ea6\u4fdd\u8bc1\u60a3\u8005\u7684\u5065\u5eb7\u3002<\/li><\/ol>

    \u300a\u56fd\u52a1\u9662\u5173\u4e8e\u5b9e\u65bd\u5065\u5eb7\u4e2d\u56fd\u884c\u52a8\u7684\u610f\u89c1\u300b \u4e00\u6587\u7684\u53d1\u5e03\uff0c\u9664\u4e86\u63d0\u9ad8\u5e7f\u5927\u7fa4\u4f17\u5bf9 \u201c\u9884\u9632\u75be\u75c5\u201d \u7684\u610f\u8bc6\uff0c\u66f4\u5173\u6ce8\u65b0\u751f\u513f\u4ee3\u8c22\u75be\u75c5\u7b5b\u67e5\uff0c\u56e0\u4e3a\u8fd9\u662f\u5bf9\u75be\u75c5\u7684\u9884\u9632\u4e0e\u63a7\u5236\u6700\u597d\u7684\u63aa\u65bd\u3002\u4e3a\u5b9e\u8df5\u5065\u5eb7\u4e2d\u56fd\u7684\u884c\u52a8\uff0c\u529b\u626c\u4ee5 DMS \u5e72\u57fa\u8d28\u70b9\u8403\u53d6\u6280\u672f\u5c06\u5065\u5eb7\u68c0\u6d4b\u81ea\u52a8\u5316\uff0c\u540c\u65f6\u5e94\u7528\u8303\u56f4\u4e0d\u65ad\u6269\u5c55\u81f3\u6cbb\u7597\u836f\u7269\u76d1\u6d4b (TDM)\u3001\u65b0\u751f\u513f\u7b5b\u67e5\u3001\u7c7b\u56fa\u9187\u6fc0\u7d20\u68c0\u6d4b\u53ca\u66f4\u591a\u76f8\u5173\u9886\u57df\uff0c\u52a1\u6c42\u5e2e\u52a9\u4eba\u4f53\u81ea\u8eab\u5065\u5eb7\u548c\u5916\u90e8\u751f\u6001\u5b89\u5168\u7684\u5168\u9762\u5b9e\u73b0\u3002\u672a\u6765\uff0c\u968f\u7740\u79d1\u6280\u7684\u9ad8\u901f\u53d1\u5c55\uff0c\u653f\u7b56\u7684\u4e0d\u65ad\u5b8c\u5584\u4e0e\u652f\u6301\uff0c\u529b\u626c\u4f01\u4e1a\u5c06\u4e0e\u66f4\u591a\u7684\u5408\u4f5c\u4f19\u4f34\u643a\u624b\u8d2f\u5f7b\u843d\u5b9e\u5065\u5eb7\u4e2d\u56fd\u884c\u52a8\uff0c\u5168\u9762\u53d1\u529b\uff0c\u62e5\u62b1\u5065\u5eb7\u672a\u6765\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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    \u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>

    1.\u00a0\u6c5f\u5dcd \u9ad8\u51e4\u8363\uff0c \u7ef4\u751f\u7d20 D \u7f3a\u4e4f\u76f8\u5173\u6027\u75be\u75c5\u7814\u7a76\u8fdb\u5c55\u3002\u4e2d\u56fd\u9aa8\u8d28\u758f\u677e\u6742\u5fd7 2014 \u5e74 3 \u6708\u7b2c 20 \u5377\u7b2c 3 \u671f\u3002<\/span><\/p>

    \uff12. Phinney KW, Bedner M, Tai SS, et al. Development and certification of a standard reference material for vitamin D metabolites in human serum. Anal Chem. 2012;84(2):956\u2013962. doi:10.1021\/ac202047n<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

    \u524d\u6bb5\u65f6\u95f4\uff0c\u56fd\u52a1\u9662\u5370\u53d1\u4e86 \u300a\u56fd\u52a1\u9662\u5173\u4e8e\u5b9e\u65bd\u5065\u5eb7\u4e2d\u56fd\u884c\u52a8\u7684\u610f\u89c1\u300b \u4e00\u6587\uff0c\u7740\u91cd\u660e\u786e\u4e86 \u201c\u5168\u65b9\u4f4d\u5e72\u9884\u5065\u5eb7\u56e0\u7d20\u201d\u3001\u201c\u7ef4\u62a4\u751f\u547d\u5468\u671f\u5065\u5eb7\u201d \u53ca \u201c\u52a0\u5f3a\u91cd\u5927\u75be\u75c5\u9632\u63a7\u201d \u4e09\u4e2a\u65b9\u9762\u7684\u4e13\u9879\u884c\u52a8\uff0c\u529b\u6c42\u53ca\u65f6\u660e\u786e\u75be\u75c5\u539f\u56e0\u4ee5\u63a7\u5236\u75c5\u60c5\u3002 \u4ece\u56fd\u52a1\u9662\u53d1\u5e03\u7684\u4e00\u6587\u4e2d\uff0c\u6211\u4eec\u4e0d\u96be\u53d1\u73b0 \u201c\u7cbe\u51c6\u4e86\u89e3\u5065\u5eb7\u95ee\u9898\u201d \u7684\u91cd\u8981\u6027\u3002\u7279\u522b\u662f\u8fd1\u5e74\u6765\uff0c\u6211\u56fd\u75be\u75c5\u8c31\u66f4\u662f\u4e0d\u65ad\u53d8\u5316\uff0c\u9700\u8981\u505a\u597d\u75c5\u60c5\u76d1\u6d4b\uff0c\u624d\u80fd\u53ca\u65f6\u5730\u53d1\u73b0\u95ee\u9898\u5e76\u505a\u597d\u9884\u9632\u63aa\u65bd\u3002 \u4eba\u4f53\u6f5c\u5728\u7684\u75be\u75c5\u662f\u5f02\u5e38\u7e41\u591a\u7684\uff0c\u540c\u65f6\u5bf9\u5065\u5eb7\u4e5f\u5b58\u5728\u7740\u6781\u5927\u7684\u5a01\u80c1\uff0c\u4e3e\u4e2a\u4f8b\u5b50, \u8fd1\u671f\u5927\u5bb6\u5bf9\u81ea\u8eab\u7684\u7ef4\u751f\u7d20 D \u90fd\u975e\u5e38\u5173\u6ce8, \u56e0\u4e3a\u7f3a\u4e4f\u5b83\u6709\u53ef\u80fd\u9020\u6210\u591a\u79cd\u9aa8\u9abc\u75be\u75c5\uff0c\u5982\u8425\u517b\u6027\u4f5d\u507b\u75c5\u3001\u8f6f\u9aa8\u75c5\u3001\u9aa8\u8d28\u758f\u677e\uff1b\u7ef4\u751f\u7d20 D \u7f3a\u4e4f\u8fd8\u4e0e\u591a\u79cd\u9aa8\u9abc\u5916\u75be\u75c5\u5bc6\u5207\u76f8\u5173\uff0c\u5982\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u80a5\u80d6\u3001\u7cd6\u5c3f\u75c5\u3001\u6076\u6027\u80bf\u7624\u3001\u611f\u67d3\u3001\u8fc7\u654f\u6027\u75be\u75c5\u53ca\u54ee\u5598\u3001\u7cbe\u795e\u53ca\u795e\u7ecf\u75be\u75c5\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u6162\u6027\u80be\u75c5\u7b49\u3002[1] \uff08\u56fe\u7247\u6e90\u4e8e\u7f51\u7edc\uff09 \u7ef4\u751f\u7d20\u00a0D (Vitamin D) \u4e3a\u4eba\u4f53\u5fc5\u9700\u7684\u4e00\u79cd\u8102\u6eb6\u6027\u7ef4\u751f\u7d20\uff0c\u5bf9\u7ef4\u6301\u4eba\u4f53\u9499\u7684\u52a8\u6001\u5e73\u8861\u65b9\u9762\u8d77\u7740\u975e\u5e38\u91cd\u8981\u7684\u4f5c\u7528\u3002\u4e3a\u6b64\uff0c\u8bb8\u591a\u7814\u7a76\u4eba\u5458\u5bf9\u7ef4\u751f\u7d20 D \u7f3a\u4e4f\u75c7\u7684\u5174\u8da3\u9010\u6e10\u589e\u52a0\u3002\u636e 1997 \u5e74\u516c\u5e03\u7ef4\u751f\u7d20 D \u7684\u53c2\u8003\u6444\u5165\uff0c\u8840\u6e05 25 \u7f9f\u57fa\u7ef4\u751f\u7d20 D [25(OH)D] \u88ab\u5b9a\u4e49\u4e3a\u53cd\u6620\u4eba\u4f53\u5185\u7ef4\u751f\u7d20 D \u72b6\u6001\u7684\u6700\u4f73\u6307\u6807\u3002 \u76ee\u524d\uff0c\u53ef\u7528\u4e8e\u6d4b\u91cf 25(OH)D \u6709\u591a\u79cd\u65b9\u6848\uff0c\u5982\u9176\u8054\u514d\u75ab\u6cd5\u3001\u653e\u5c04\u514d\u75ab\u6280\u672f\u7b49\uff0c\u8f83\u4e3a\u5148\u8fdb\u7684\u6280\u672f\u662f\u6db2\u76f8\u8272\u8c31\u4e32\u8054\u8d28\u8c31\u6280\u672f (LC-MS\/MS)\uff0c\u5177\u6709\u9ad8\u7279\u5f02\u6027\u3001\u9ad8\u9009\u62e9\u6027\u3001\u9ad8\u7075\u654f\u5ea6\u3001\u68c0\u6d4b\u5feb\u901f\u7b49\u72ec\u7279\u4f18\u52bf\uff0cLC-MS\/MS \u4ea6\u5df2\u88ab\u7f8e\u56fd\u56fd\u5bb6\u6807\u51c6\u6280\u672f\u7814\u7a76\u6240 (NIST) \u8a89\u4e3a\u89c4\u8303\u5316\u6d4b\u91cf 25(OH)D \u7684 \u201c\u91d1\u6807\u51c6\uff02[\uff12]\u3002 \u4f46\u5bf9\u4e8e 25(OH)D \u6d4b\u91cf\u7684\u96be\u70b9\u5728\u4e8e\u6837\u54c1\u524d\u5904\u7406 (Sample Preparation)\uff0c\u5176\u539f\u56e0\u5728\u4e8e\u8840\u6db2\u6837\u54c1\u57fa\u8d28\u7684\u590d\u6742\u6027\uff0c\u73b0\u6709\u7684\u65b9\u6cd5\u9700\u8981\u505a\u884d\u751f\u5316\uff0c\u4e0d\u4ec5\u6b65\u9aa4\u7e41\u7410\uff0c\u800c\u4e14\u6210\u672c\u9ad8\u3002\u968f\u7740\u6d4b\u91cf\u9700\u6c42\u65e5\u76ca\u589e\u591a\uff0c\u6837\u54c1\u524d\u5904\u7406\u5de5\u4f5c\u5360\u7528\u4e86\u5927\u91cf\u4eba\u529b\uff0c\u6210\u4e3a\u5236\u7ea6\u4e34\u5e8a LC-MS \/ MS \u5206\u6790\u7684\u6700\u5927\u74f6\u9888\u3002 \u9488\u5bf9\u7ef4\u751f\u7d20 […]<\/p>\n","protected":false},"author":1,"featured_media":6143,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[151,333,186],"tags":[97,131],"_links":{"self":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts\/6142"}],"collection":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/comments?post=6142"}],"version-history":[{"count":6,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts\/6142\/revisions"}],"predecessor-version":[{"id":13256,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts\/6142\/revisions\/13256"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/media\/6143"}],"wp:attachment":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/media?parent=6142"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/categories?post=6142"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/tags?post=6142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}