{"id":4537,"date":"2019-03-07T18:00:34","date_gmt":"2019-03-07T10:00:34","guid":{"rendered":"http:\/\/www.nikyang.com\/?p=4537"},"modified":"2021-09-23T11:43:22","modified_gmt":"2021-09-23T03:43:22","slug":"dms-new-born-screening","status":"publish","type":"post","link":"https:\/\/www.nikyang.com\/news\/dms-new-born-screening\/","title":{"rendered":"\u65b0\u751f\u513f\u7b5b\u67e5\u65b0\u8fdb\u5c55\uff1a\u5e72\u8840\u6591\u4e2d\u7c7b\u56fa\u9187\u7684\u5168\u81ea\u52a8\u5206\u6790"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"4537\" class=\"elementor elementor-4537 elementor-bc-flex-widget\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t<div class=\"elementor-inner\">\n\t\t\t\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b188ab5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b188ab5\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-32f4421\" data-id=\"32f4421\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6567c86 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6567c86\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-64b6977\" data-id=\"64b6977\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f8c9543 elementor-widget elementor-widget-image\" data-id=\"f8c9543\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"523\" height=\"180\" src=\"\/wp-content\/uploads\/2019\/03\/Jan_WeChat4_2.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"\/wp-content\/uploads\/2019\/03\/Jan_WeChat4_2.jpg 523w, \/wp-content\/uploads\/2019\/03\/Jan_WeChat4_2-300x103.jpg 300w\" sizes=\"(max-width: 523px) 100vw, 523px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d150cfd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d150cfd\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-abb88c2\" data-id=\"abb88c2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a8ac71a elementor-widget elementor-widget-text-editor\" data-id=\"a8ac71a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>\u6700\u8fd1\u65b0\u751f\u513f\u4ee3\u8c22\u75c5\u7b5b\u67e5\u9886\u57df\u6743\u5a01\u6742\u5fd7 International Journal of Neonatal Screening \u53d1\u8868\u4e86\u4e00\u7bc7\u7684\u7814\u7a76\u8bba\u6587[1]\u3002\u901a\u8fc7\u5168\u81ea\u52a8\u5e72\u8840\u6591\u8403\u53d6\u7cfb\u7edf\u4e0e LC-MS \u8fdb\u884c\u5728\u7ebf\u8fde\u63a5\uff0c\u5b9e\u73b0\u4e86\u65b0\u751f\u513f\u4ee3\u8c22\u75c5\u7b5b\u67e5\u7684\u81ea\u52a8\u5316\u3002<\/p><p>\u8be5\u65b9\u6cd5\u9664\u4e86\u53ef\u4ee5\u68c0\u6d4b\u5e38\u89c4\u65b0\u7b5b\u7684\u6c28\u57fa\u9178\u548c\u9170\u57fa\u8089\u78b1\u7b49\u6307\u6807\uff0c\u8fd8<strong>\u9996\u6b21\u5b9e\u73b0\u65b0\u7b5b\u7c7b\u56fa\u9187\u7684\u8d28\u8c31\u68c0\u6d4b<\/strong>\uff0c\u53ef\u4f5c\u4e3a<strong>\u5148\u5929\u6027\u80be\u4e0a\u817a\u589e\u751f<\/strong>\u7684\u7b5b\u67e5\u65b9\u6cd5\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cDBS-LC-MS\/MS \u7cfb\u7edf\u62e5\u6709\u4f18\u8d8a\u7684\u7ebf\u6027\uff0c\u5e76\u4e14\u51c6\u786e\u5ea6\u548c\u7cbe\u5bc6\u5ea6\u5b8c\u5168\u6ee1\u8db3 FDA \u7684\u76f8\u5173\u6807\u51c6\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-149aa4d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"149aa4d\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d56c1a8\" data-id=\"d56c1a8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4fcd7c3 elementor-widget elementor-widget-image\" data-id=\"4fcd7c3\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"504\" height=\"373\" src=\"\/wp-content\/uploads\/2019\/03\/Jan_WeChat4_3.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"\/wp-content\/uploads\/2019\/03\/Jan_WeChat4_3.jpg 504w, \/wp-content\/uploads\/2019\/03\/Jan_WeChat4_3-300x222.jpg 300w\" sizes=\"(max-width: 504px) 100vw, 504px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-330c8fa elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"330c8fa\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f6f0746\" data-id=\"f6f0746\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-01a8c38 elementor-widget elementor-widget-text-editor\" data-id=\"01a8c38\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p>\u8be5\u9879\u7814\u7a76\u4f7f\u7528\u7684<strong>\u5168\u81ea\u52a8\u5e72\u8840\u6591\u8403\u53d6\u7cfb\u7edf<\/strong> (\u745e\u58eb CAMAG DBS-MS 500) \u80fd\u5feb\u901f\u3001\u7a33\u5b9a\u5730\u5236\u5907\u6837\u672c\uff0c\u4e0e LC-MS \u8054\u7528\u53ef\u5b9e\u73b0\u5feb\u901f\u3001\u9ad8\u6548\u7684\u5168\u81ea\u52a8\u65b0\u751f\u513f\u4ee3\u8c22\u75c5\u7b5b\u67e5\u89e3\u51b3\u65b9\u6848\u3002\u9664\u4e86\u80fd\u8986\u76d6\u6240\u6709\u4e34\u5e8a\u76f8\u5173\u6c28\u57fa\u9178\u548c\u9170\u57fa\u8089\u78b1\u7684\u68c0\u6d4b\uff0c\u8be5\u65b9\u6cd5\u8fd8\u9996\u6b21\u6574\u5408\u4e86\u7c7b\u80c6\u56fa\u9187\u7684\u68c0\u6d4b\u3002\u56e0\u6b64\uff0c\u76f8\u6bd4\u4e8e\u76ee\u524d\u4f7f\u7528\u7684\u751f\u7269\u68c0\u6d4b\uff0c\u8fd9\u79cd\u65b9\u6cd5\u66f4\u9002\u5408\u5148\u5929\u6027\u80be\u4e0a\u817a\u589e\u751f\u7684\u7b5b\u67e5\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b75fc6a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b75fc6a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e77727a\" data-id=\"e77727a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5fd02f1 elementor-widget elementor-widget-image\" data-id=\"5fd02f1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"580\" height=\"428\" src=\"\/wp-content\/uploads\/2018\/11\/Oct_WeChat2_3.jpg\" class=\"attachment-large size-large\" alt=\"\u63d0\u53d6\u5e72\u8840\u6591\" srcset=\"\/wp-content\/uploads\/2018\/11\/Oct_WeChat2_3.jpg 580w, \/wp-content\/uploads\/2018\/11\/Oct_WeChat2_3-300x221.jpg 300w\" sizes=\"(max-width: 580px) 100vw, 580px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-879e226 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"879e226\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-02fa9ea\" data-id=\"02fa9ea\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-516159a elementor-widget elementor-widget-text-editor\" data-id=\"516159a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<h6><strong>\u4f18\u70b9\u4e00\uff1a\u652f\u6301\u8d85\u9ad8\u538b UPLC\uff0c\u52a0\u901f\u6837\u54c1\u5206\u6790<\/strong><\/h6><p>DBS-LC-MS\/MS \u7cfb\u7edf\u80fd\u591f\u5728\u5206\u6790\u4e2d\u627f\u53d7\u9ad8\u8fbe 1200 \u5df4\u7684\u538b\u529b\uff0c\u56e0\u6b64\u53ef\u4ee5\u4f7f\u7528\u66f4\u5c0f\u7c92\u5f84\u586b\u6599\u7684\u8272\u8c31\u67f1\u548c UPLC \u7cfb\u7edf\u3002\u8fd9\u6837\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u5c06\u5355\u6b21\u68c0\u6d4b\u65f6\u95f4\u7f29\u77ed\u5230\u5230 <strong>2.5 \u5206\u949f\/\u6837\u54c1<\/strong>\uff0c\u4e0d\u95f4\u65ad\u5904\u7406 2000 \u4e2a\u6837\u54c1\u3002<\/p><h6><strong>\u4f18\u70b9\u4e8c\uff1a\u4f4e\u6d88\u8017\uff0c\u66f4\u4f18\u7684\u5185\u6807\u52a0\u5165\u65b9\u6848<\/strong><\/h6><p>\u5728\u5927\u591a\u6570\u5904\u7406 DBS \u65b9\u6848\u4e2d\uff0c\u81f3\u5c11\u9700\u8981 100 \u5fae\u5347\u7684\u63d0\u53d6\u6eb6\u6db2\u548c\u5185\u6807\u52a0\u6837\u54c1\u5236\u5907\u6d88\u8017\u54c1\uff0c\u7136\u800c\u4f7f\u7528 DBS-MS 500 \u7cfb\u7edf\u53ea\u9700\u8981 20 \u5fae\u5347\u8403\u53d6\u6db2\u5e76\u4e14\u5728\u8403\u53d6\u524d\u4f18\u5148\u52a0\u5165\u5185\u6807\u3002 (\u5c06\u5185\u6807\u5c3d\u65e9\u52a0\u5165\u5de5\u4f5c\u6d41\u7a0b\u4e2d\u53ef\u4ee5\u76d1\u63a7\u63d0\u53d6\u6548\u7387\u548c\u9075\u5faa\u65b9\u5f00\u53d1\u6307\u5357\u3002)<\/p><h6><strong>\u4f18\u70b9\u4e09\uff1a\u5b8c\u6574\u7684\u6837\u54c1\u548c\u8fc7\u7a0b\u6570\u636e\uff0c\u66f4\u597d\u7684\u8d28\u91cf\u63a7\u5236<\/strong><\/h6><p>\u81ea\u52a8\u8bfb\u53d6\u6837\u54c1\u4fe1\u606f\uff0c\u8403\u53d6\u524d\u540e\u8fdb\u884c\u56fe\u50cf\u5206\u6790\uff0c\u6240\u6709\u7684\u6837\u54c1\u5236\u5907\u53c2\u6570\u548c\u6837\u54c1\u72b6\u6001\u53c2\u6570\u90fd\u53ef\u8bb0\u5f55\u5e76\u6574\u5408\u5230\u5206\u6790\u7ed3\u679c\u4e2d\uff0c\u6709\u5229\u4e8e\u5206\u6790\u8fc7\u7a0b\u4e2d\u7684\u968f\u65f6\u8ffd\u8e2a\u548c\u8d28\u91cf\u63a7\u5236\u3002\u6240\u6709\u6570\u636e\u6574\u5408\u5230\u4e00\u4e2a\u6587\u4ef6\u7cfb\u7edf\uff0c\u4e3a GLP (Good Laboratory Practice) \u6253\u4e0b\u57fa\u7840\u3002<\/p><p>[1] Stefan Gaugler, et al. Extended and Fully Automated Newborn Screening Method for Mass Spectrometry Detection Int. J. Neonatal Screen. 2018, 4, 2.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ddc0a31 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ddc0a31\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b8ab33e\" data-id=\"b8ab33e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3a043eb elementor-widget elementor-widget-image\" data-id=\"3a043eb\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"900\" height=\"753\" src=\"\/wp-content\/uploads\/2018\/11\/Oct_WeChat4_4-1024x857.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"\/wp-content\/uploads\/2018\/11\/Oct_WeChat4_4-1024x857.jpg 1024w, \/wp-content\/uploads\/2018\/11\/Oct_WeChat4_4-300x251.jpg 300w, \/wp-content\/uploads\/2018\/11\/Oct_WeChat4_4-768x643.jpg 768w, \/wp-content\/uploads\/2018\/11\/Oct_WeChat4_4-600x502.jpg 600w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u6700\u8fd1\u65b0\u751f\u513f\u4ee3\u8c22\u75c5\u7b5b\u67e5\u9886\u57df\u6743\u5a01\u6742\u5fd7 International Journal of Neonatal Screening \u53d1\u8868\u4e86\u4e00\u7bc7\u7684\u7814\u7a76\u8bba\u6587[1]\u3002\u901a\u8fc7\u5168\u81ea\u52a8\u5e72\u8840\u6591\u8403\u53d6\u7cfb\u7edf\u4e0e LC-MS \u8fdb\u884c\u5728\u7ebf\u8fde\u63a5\uff0c\u5b9e\u73b0\u4e86\u65b0\u751f\u513f\u4ee3\u8c22\u75c5\u7b5b\u67e5\u7684\u81ea\u52a8\u5316\u3002 \u8be5\u65b9\u6cd5\u9664\u4e86\u53ef\u4ee5\u68c0\u6d4b\u5e38\u89c4\u65b0\u7b5b\u7684\u6c28\u57fa\u9178\u548c\u9170\u57fa\u8089\u78b1\u7b49\u6307\u6807\uff0c\u8fd8\u9996\u6b21\u5b9e\u73b0\u65b0\u7b5b\u7c7b\u56fa\u9187\u7684\u8d28\u8c31\u68c0\u6d4b\uff0c\u53ef\u4f5c\u4e3a\u5148\u5929\u6027\u80be\u4e0a\u817a\u589e\u751f\u7684\u7b5b\u67e5\u65b9\u6cd5\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0cDBS-LC-MS\/MS \u7cfb\u7edf\u62e5\u6709\u4f18\u8d8a\u7684\u7ebf\u6027\uff0c\u5e76\u4e14\u51c6\u786e\u5ea6\u548c\u7cbe\u5bc6\u5ea6\u5b8c\u5168\u6ee1\u8db3 FDA \u7684\u76f8\u5173\u6807\u51c6\u3002 \u8be5\u9879\u7814\u7a76\u4f7f\u7528\u7684\u5168\u81ea\u52a8\u5e72\u8840\u6591\u8403\u53d6\u7cfb\u7edf (\u745e\u58eb CAMAG DBS-MS 500) \u80fd\u5feb\u901f\u3001\u7a33\u5b9a\u5730\u5236\u5907\u6837\u672c\uff0c\u4e0e LC-MS \u8054\u7528\u53ef\u5b9e\u73b0\u5feb\u901f\u3001\u9ad8\u6548\u7684\u5168\u81ea\u52a8\u65b0\u751f\u513f\u4ee3\u8c22\u75c5\u7b5b\u67e5\u89e3\u51b3\u65b9\u6848\u3002\u9664\u4e86\u80fd\u8986\u76d6\u6240\u6709\u4e34\u5e8a\u76f8\u5173\u6c28\u57fa\u9178\u548c\u9170\u57fa\u8089\u78b1\u7684\u68c0\u6d4b\uff0c\u8be5\u65b9\u6cd5\u8fd8\u9996\u6b21\u6574\u5408\u4e86\u7c7b\u80c6\u56fa\u9187\u7684\u68c0\u6d4b\u3002\u56e0\u6b64\uff0c\u76f8\u6bd4\u4e8e\u76ee\u524d\u4f7f\u7528\u7684\u751f\u7269\u68c0\u6d4b\uff0c\u8fd9\u79cd\u65b9\u6cd5\u66f4\u9002\u5408\u5148\u5929\u6027\u80be\u4e0a\u817a\u589e\u751f\u7684\u7b5b\u67e5\u3002 \u4f18\u70b9\u4e00\uff1a\u652f\u6301\u8d85\u9ad8\u538b UPLC\uff0c\u52a0\u901f\u6837\u54c1\u5206\u6790 DBS-LC-MS\/MS \u7cfb\u7edf\u80fd\u591f\u5728\u5206\u6790\u4e2d\u627f\u53d7\u9ad8\u8fbe 1200 \u5df4\u7684\u538b\u529b\uff0c\u56e0\u6b64\u53ef\u4ee5\u4f7f\u7528\u66f4\u5c0f\u7c92\u5f84\u586b\u6599\u7684\u8272\u8c31\u67f1\u548c UPLC \u7cfb\u7edf\u3002\u8fd9\u6837\u53ef\u4ee5\u5f88\u5bb9\u6613\u5730\u5c06\u5355\u6b21\u68c0\u6d4b\u65f6\u95f4\u7f29\u77ed\u5230\u5230 2.5 \u5206\u949f\/\u6837\u54c1\uff0c\u4e0d\u95f4\u65ad\u5904\u7406 2000 \u4e2a\u6837\u54c1\u3002 \u4f18\u70b9\u4e8c\uff1a\u4f4e\u6d88\u8017\uff0c\u66f4\u4f18\u7684\u5185\u6807\u52a0\u5165\u65b9\u6848 \u5728\u5927\u591a\u6570\u5904\u7406 DBS \u65b9\u6848\u4e2d\uff0c\u81f3\u5c11\u9700\u8981 100 \u5fae\u5347\u7684\u63d0\u53d6\u6eb6\u6db2\u548c\u5185\u6807\u52a0\u6837\u54c1\u5236\u5907\u6d88\u8017\u54c1\uff0c\u7136\u800c\u4f7f\u7528 DBS-MS 500 \u7cfb\u7edf\u53ea\u9700\u8981 20 \u5fae\u5347\u8403\u53d6\u6db2\u5e76\u4e14\u5728\u8403\u53d6\u524d\u4f18\u5148\u52a0\u5165\u5185\u6807\u3002 (\u5c06\u5185\u6807\u5c3d\u65e9\u52a0\u5165\u5de5\u4f5c\u6d41\u7a0b\u4e2d\u53ef\u4ee5\u76d1\u63a7\u63d0\u53d6\u6548\u7387\u548c\u9075\u5faa\u65b9\u5f00\u53d1\u6307\u5357\u3002) \u4f18\u70b9\u4e09\uff1a\u5b8c\u6574\u7684\u6837\u54c1\u548c\u8fc7\u7a0b\u6570\u636e\uff0c\u66f4\u597d\u7684\u8d28\u91cf\u63a7\u5236 \u81ea\u52a8\u8bfb\u53d6\u6837\u54c1\u4fe1\u606f\uff0c\u8403\u53d6\u524d\u540e\u8fdb\u884c\u56fe\u50cf\u5206\u6790\uff0c\u6240\u6709\u7684\u6837\u54c1\u5236\u5907\u53c2\u6570\u548c\u6837\u54c1\u72b6\u6001\u53c2\u6570\u90fd\u53ef\u8bb0\u5f55\u5e76\u6574\u5408\u5230\u5206\u6790\u7ed3\u679c\u4e2d\uff0c\u6709\u5229\u4e8e\u5206\u6790\u8fc7\u7a0b\u4e2d\u7684\u968f\u65f6\u8ffd\u8e2a\u548c\u8d28\u91cf\u63a7\u5236\u3002\u6240\u6709\u6570\u636e\u6574\u5408\u5230\u4e00\u4e2a\u6587\u4ef6\u7cfb\u7edf\uff0c\u4e3a GLP (Good Laboratory Practice) \u6253\u4e0b\u57fa\u7840\u3002 [1] Stefan Gaugler, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4539,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[151,333,186],"tags":[97,131,593],"_links":{"self":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts\/4537"}],"collection":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/comments?post=4537"}],"version-history":[{"count":5,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts\/4537\/revisions"}],"predecessor-version":[{"id":5375,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts\/4537\/revisions\/5375"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/media\/4539"}],"wp:attachment":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/media?parent=4537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/categories?post=4537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/tags?post=4537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}