{"id":18152,"date":"2023-11-16T09:59:59","date_gmt":"2023-11-16T01:59:59","guid":{"rendered":"https:\/\/www.nikyang.com\/?p=18152"},"modified":"2023-11-16T10:24:42","modified_gmt":"2023-11-16T02:24:42","slug":"dissolution-nanosuspensions","status":"publish","type":"post","link":"https:\/\/www.nikyang.com\/news\/dissolution-nanosuspensions\/","title":{"rendered":"\u6eb6\u51fa\u5ea6\u7814\u7a76 | \u7eb3\u7c73\u6df7\u60ac\u6db2\u7684\u6eb6\u51fa\u5ea6\u6d4b\u8bd5"},"content":{"rendered":"\n<p>\u7eb3\u7c73\u6df7\u60ac\u6db2\u7ed9\u836f\u7cfb\u7edf\u662f\u4e00\u79cd\u65b0\u578b\u7684\u7ed9\u836f\u7cfb\u7edf\u3002\u5c06\u836f\u7269\u505a\u6210\u7eb3\u7c73\u6df7\u60ac\u5242\u6709\u5229\u4e8e\u589e\u52a0\u836f\u7269\u6eb6\u51fa\u5ea6\u548c\u63d0\u9ad8\u751f\u7269\u5229\u7528\u5ea6\u3002\u5bf9\u4e8e\u96be\u6eb6\u6027\u836f\u7269\uff0c\u505a\u6210\u7eb3\u7c73\u6df7\u60ac\u5242\uff0c\u53ef\u6539\u5584\u5176\u4f53\u5185\u836f\u7269\u52a8\u529b\u5b66\u884c\u4e3a\uff0c\u63d0\u9ad8\u836f\u6548\u3002<\/p>\n\n\n\n<p>\u4e0d\u540c\u5de5\u827a\u4e0b\u7684\u7eb3\u7c73\u6df7\u60ac\u5242\uff0c\u53d7\u5176\u5904\u65b9\u6210\u5206\u5dee\u5f02\u3001API\u7c92\u5f84\u5206\u5e03\u3001\u6676\u578b\u7b49\u5f71\u54cd\uff0c\u6eb6\u51fa\u884c\u4e3a\u53ef\u80fd\u6709\u5dee\u5f02\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img width=\"755\" height=\"429\" src=\"\/wp-content\/uploads\/2023\/11\/\u5716\u7247-1.jpg\" alt=\"\" class=\"wp-image-18153\" srcset=\"\/wp-content\/uploads\/2023\/11\/\u5716\u7247-1.jpg 755w, \/wp-content\/uploads\/2023\/11\/\u5716\u7247-1-300x170.jpg 300w\" sizes=\"(max-width: 755px) 100vw, 755px\" \/><figcaption><sub>\uff08\u5f15\u7528\u81ea\u6587\u732e[1]\uff09<\/sub><\/figcaption><\/figure>\n\n\n\n<p>\u56e0\u6b64\uff0c\u6eb6\u51fa\u5b9e\u9a8c\u4e5f\u662f\u7eb3\u7c73\u6df7\u60ac\u5242\u7814\u7a76\u7684\u91cd\u8981\u624b\u6bb5\u3002\u90a3\u4e48\uff0c\u4e0d\u540c\u5236\u5242\u5de5\u827a\u4e0b\u5f97\u5230\u7684\u4e0d\u540c\u6279\u6b21\u7eb3\u7c73\u6df7\u60ac\u5242\uff0c\u6211\u4eec\u8be5\u5982\u4f55\u6d4b\u8bd5\u5b83\u4eec\u7684\u6eb6\u51fa\u884c\u4e3a\u662f\u5426\u6709\u660e\u663e\u5dee\u5f02\uff1f\u6eb6\u51fa\u5ea6\u6d4b\u8bd5\u5e94\u8be5\u5982\u4f55\u8fdb\u884c\uff1f<\/p>\n\n\n\n<p>\u4ece\u6df7\u60ac\u5242\u6eb6\u51fa\u5b9e\u9a8c\u7684\u89d2\u5ea6\u770b\uff0c\u4f7f\u7528\u6868\u6cd5\uff0c\u76f4\u63a5\u5c06\u6df7\u60ac\u5242\u6295\u5230\u6eb6\u51fa\u676f\u8fdb\u884c\u6eb6\u51fa\u5b9e\u9a8c\uff0c\u4f3c\u4e4e\u662f\u53ef\u884c\u7684\u65b9\u6848\u3002\u7684\u786e\uff0c\u6868\u6cd5\u4e5f\u662f\u6df7\u60ac\u5236\u5242\u4e2d\u6bd4\u8f83\u5e38\u7528\u7684\u65b9\u6cd5\uff0c\u4f46\u5f53\u4e2d\u53ef\u80fd\u5b58\u5728\u4e00\u4e9b\u95ee\u9898\uff0c\u5f71\u54cd\u5b9e\u9a8c\u7ed3\u679c\uff0c\u4e0b\u9762\u5217\u4e3e\u4e00\u4e2a\u4f8b\u5b50\uff1a<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><strong><span class=\"has-inline-color has-vivid-cyan-blue-color\">\u6868<\/span><\/strong><span class=\"has-inline-color has-vivid-cyan-blue-color\"><strong>\u6cd5\u00a0<\/strong>&#8211; \u7528\u79fb\u6db2\u67aa\u79fb\u53d6\u4e00\u5b9a\u4f53\u79ef\u7684\u6df7\u60ac\u5242\uff0c\u52a0\u5165\u6eb6\u51fa\u676f\u4e2d<\/span><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img width=\"658\" height=\"508\" src=\"\/wp-content\/uploads\/2023\/11\/\u5716\u7247-2.png\" alt=\"\" class=\"wp-image-18154\" srcset=\"\/wp-content\/uploads\/2023\/11\/\u5716\u7247-2.png 658w, \/wp-content\/uploads\/2023\/11\/\u5716\u7247-2-300x232.png 300w\" sizes=\"(max-width: 658px) 100vw, 658px\" \/><\/figure>\n\n\n\n<p>\u5728\u6868\u6cd5\u7684\u6eb6\u51fa\u5ea6\u5b9e\u9a8c\u4e0b\uff0c\u7eb3\u7c73\u6df7\u60ac\u5242\u7684<strong>\u6837\u54c1\u91ca\u653e\u901f\u5ea6\u8fc7\u5feb\uff0c\u65e0\u6cd5\u6bd4\u8f83\u4e0d\u540c\u6279\u6b21\u6837\u54c1\u7684\u6eb6\u51fa\u5dee\u5f02<\/strong>\u3002\u4ed4\u7ec6\u601d\u8003\u6868\u6cd5\u7684\u6eb6\u51fa\u5b9e\u9a8c\u8fc7\u7a0b\uff0c\u6211\u4eec\u53ef\u4ee5\u627e\u51fa\u5f53\u4e2d\u7684\u95ee\u9898\uff1a<\/p>\n\n\n\n<ul><li>\u79fb\u6db2\u67aa\u79fb\u53d6\u7eb3\u7c73\u6df7\u60ac\u5242\uff0c6\u4e2a\u5e73\u884c\u6837\u54c1\uff0c\u52a0\u6837\u7684\u65f6\u50196\u676f\u7684\u52a0\u6837\u6709\u65f6\u95f4\u5dee\uff0c\u6837\u54c1\u7684\u6eb6\u51fa\u5728\u6df7\u60ac\u5242\u4e0e\u6eb6\u51fa\u4ecb\u8d28\u63a5\u89e6\u65f6\u5df2\u7ecf\u5f00\u59cb\uff1b<\/li><\/ul>\n\n\n\n<ul><li>\u7eb3\u7c73\u6df7\u60ac\u5242\u52a0\u5165\u5230\u6eb6\u51fa\u676f\u65f6\u7684\u9ad8\u5ea6\u3001\u4f4d\u7f6e\u53ef\u80fd\u51fa\u73b0\u5dee\u5f02\uff0c\u5f71\u54cd\u6eb6\u51fa\u7ed3\u679c\uff1b<\/li><\/ul>\n\n\n\n<ul><li>\u5c0f\u4f53\u79ef\u7684\u7eb3\u7c73\u6df7\u60ac\u5242\u4e00\u4e0b\u5b50\u52a0\u5165\u5230\u6bd4\u8f83\u5927\u4f53\u79ef\u7684\u6eb6\u51fa\u4ecb\u8d28\u4e2d\uff0c\u53ef\u80fd\u77ac\u95f4\u5df2\u5b8c\u5168\u6eb6\u51fa\uff1b<\/li><\/ul>\n\n\n\n<ul><li>\u7eb3\u7c73\u6df7\u60ac\u5242\u5206\u6563\u5728\u6eb6\u51fa\u4ecb\u8d28\u4e2d\uff0c\u53ef\u80fd\u5728\u53d6\u6837\u65f6\uff0c\u628a\u6ca1\u6eb6\u51fa\u7684\u6837\u54c1\u53d6\u8d70\uff0c\u5f71\u54cd\u6eb6\u51fa\u7ed3\u679c\u3002<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p><span class=\"has-inline-color has-vivid-cyan-blue-color\"><strong>\u6d41\u6c60\u6cd5\u00a0<\/strong>&#8211; \u6df7\u60ac\u5242\u88ab\u8f7d\u5165\u6d41\u901a\u6c60\uff0c\u4ee5\u95ed\u73af\u7cfb\u7edf\u5b8c\u6210\u5b9e\u9a8c<\/span><\/p>\n\n\n\n<p>\u9664\u4e86\u6868\u6cd5\uff0c\u5f53\u7136\u6211\u4eec\u53ef\u4ee5\u8003\u8651\u4f7f\u7528\u6d41\u6c60\u6cd5\u8fdb\u884c\u5b9e\u9a8c\u3002\u6d41\u6c60\u6cd5\u662f\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u51782020\u7248\u300b\u65b0\u589e\u7684\u65b9\u6cd5\uff0c\u56e0\u5176\u7075\u6d3b\u6027\u548c\u9002\u7528\u8303\u56f4\u5e7f\u6cdb\uff0c\u5728\u6df7\u60ac\u5242\u7684\u6eb6\u51fa\u7814\u7a76\u4e2d\u4e5f\u9002\u7528\u3002\u800c<strong>\u6d41\u6c60\u6cd5\u7684\u95ed\u73af\u7cfb\u7edf\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u7f13\u6162\u91ca\u653e\u7684\u6837\u54c1<\/strong>\uff0c\u8ba9\u6837\u54c1\u6162\u6162\u6eb6\u51fa\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img width=\"1006\" height=\"704\" src=\"\/wp-content\/uploads\/2023\/11\/\u5716\u7247-4.png\" alt=\"\" class=\"wp-image-18155\" srcset=\"\/wp-content\/uploads\/2023\/11\/\u5716\u7247-4.png 1006w, \/wp-content\/uploads\/2023\/11\/\u5716\u7247-4-300x210.png 300w, \/wp-content\/uploads\/2023\/11\/\u5716\u7247-4-768x537.png 768w\" sizes=\"(max-width: 1006px) 100vw, 1006px\" \/><figcaption><sub>\uff08\u7c92\u5f84\uff1a\u6837\u54c11\uff1c\u6837\u54c12\uff09<\/sub><\/figcaption><\/figure>\n\n\n\n<p>\u4ece\u6d41\u6c60\u6cd5\u7684\u7ed3\u679c\u4e2d\u770b\u51fa\uff0c\u7eb3\u7c73\u6df7\u60ac\u5242\u7f13\u6162\u6eb6\u51fa\uff0c\u4e0d\u540c\u7684\u7eb3\u7c73\u6df7\u60ac\u5242\u6eb6\u51fa\u6709\u5dee\u5f02\u3002\u76f8\u6bd4\u4e8e\u6868\u6cd5\uff0c\u6d41\u6c60\u6cd5\u6709\u4ee5\u4e0b\u4f18\u52bf\uff1a<\/p>\n\n\n\n<ul><li>\u7eb3\u7c73\u6df7\u60ac\u5242\u88ab\u8f7d\u5165\u6d41\u901a\u6c60\u4e2d\uff0c\u52a0\u6837\u4f4d\u7f6e\u76f8\u5bf9\u56fa\u5b9a\uff1b<\/li><\/ul>\n\n\n\n<ul><li>\u7eb3\u7c73\u6df7\u60ac\u5242\u5728\u5b9e\u9a8c\u5f00\u59cb\u540e\u624d\u4e0e\u6eb6\u51fa\u4ecb\u8d28\u63a5\u89e6\uff0c\u624d\u5f00\u59cb\u6eb6\u51fa\u7684\u8fc7\u7a0b\uff1b<\/li><\/ul>\n\n\n\n<ul><li>\u7eb3\u7c73\u6df7\u60ac\u5242\u53ef\u4ee5\u88ab\u6ee4\u819c\u963b\u6321\u5728\u6d41\u901a\u6c60\u4e2d\uff0c\u6eb6\u51fa\u8fc7\u7a0b\u5728\u6d41\u901a\u6c60\u4e2d\u53d1\u751f\uff1b<\/li><\/ul>\n\n\n\n<ul><li>\u6d41\u901a\u6c60\u6c60\u5b50\u4f53\u79ef\u8f83\u5c0f\uff0c\u5e76\u4e14\u5728\u6eb6\u51fa\u539f\u7406\u4e0a\u5176\u52a8\u529b\u66f4\u6e29\u548c\uff0c\u80fd\u5f97\u5230\u8f83\u7f13\u6162\u7684\u6eb6\u51fa\u66f2\u7ebf\u3002<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image size-full\"><img width=\"691\" height=\"334\" src=\"\/wp-content\/uploads\/2023\/11\/\u87a2\u5e55\u622a\u5716-2023-11-08-\u4e0b\u53485.19.11.png\" alt=\"\" class=\"wp-image-18156\" srcset=\"\/wp-content\/uploads\/2023\/11\/\u87a2\u5e55\u622a\u5716-2023-11-08-\u4e0b\u53485.19.11.png 691w, \/wp-content\/uploads\/2023\/11\/\u87a2\u5e55\u622a\u5716-2023-11-08-\u4e0b\u53485.19.11-300x145.png 300w\" sizes=\"(max-width: 691px) 100vw, 691px\" \/><\/figure>\n\n\n\n<p>\u4e00\u7bc7\u53d1\u5e03\u5728Molecular Pharmaceutics\u7684\u6587\u732e[1]\uff0c\u4e5f\u5229\u7528\u6d41\u6c60\u6cd5\u8fdb\u884c\u4e86\u7eb3\u7c73\u6df7\u60ac\u5242\u7684\u4f53\u5916\u91ca\u653e\u5ea6\u7814\u7a76\u3002\u5728\u6eb6\u51fa\u8fc7\u7a0b\u4e2d\uff0c<strong>\u7eb3\u7c73\u6df7\u60ac\u5242\u88ab\u88c5\u8f7d\u5728\u6d41\u901a\u6c60\u4e2d\u7684\uff0c\u5df2\u6eb6\u51fa\u7684API\u53ef\u4ee5\u900f\u8fc7\u6ee4\u819c\u6d41\u51fa\u6d41\u901a\u6c60\uff0c\u800c\u6ca1\u6709\u6eb6\u51fa\u7684API\u5219\u88ab\u963b\u6321\u5728\u6d41\u901a\u6c60\u91cc\u7ee7\u7eed\u6eb6\u51fa<\/strong>\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img width=\"604\" height=\"468\" src=\"\/wp-content\/uploads\/2023\/11\/\u5716\u7247-5.jpg\" alt=\"\" class=\"wp-image-18157\" srcset=\"\/wp-content\/uploads\/2023\/11\/\u5716\u7247-5.jpg 604w, \/wp-content\/uploads\/2023\/11\/\u5716\u7247-5-300x232.jpg 300w\" sizes=\"(max-width: 604px) 100vw, 604px\" \/><figcaption><sub>\uff08\u5f15\u7528\u81ea\u6587\u732e[1]\uff09<\/sub><\/figcaption><\/figure>\n\n\n\n<p>\u5bf9\u6d41\u6c60\u6cd5\u65b9\u6cd5\u8fdb\u884c\u4f18\u5316\u540e\uff0c\u53ef\u4ee5\u8fdb\u884c\u4e0d\u540c\u6837\u54c1\u7684\u6eb6\u51fa\u5b9e\u9a8c\uff0c\u6709\u6548\u5bf9\u6bd4\u6eb6\u51fa\u884c\u4e3a\u7684\u5dee\u5f02\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img width=\"427\" height=\"372\" src=\"\/wp-content\/uploads\/2023\/11\/\u5716\u7247-6.jpg\" alt=\"\" class=\"wp-image-18158\" srcset=\"\/wp-content\/uploads\/2023\/11\/\u5716\u7247-6.jpg 427w, \/wp-content\/uploads\/2023\/11\/\u5716\u7247-6-300x261.jpg 300w\" sizes=\"(max-width: 427px) 100vw, 427px\" \/><figcaption><sub>\uff08\u5f15\u7528\u81ea\u6587\u732e[1]\uff09<\/sub><\/figcaption><\/figure>\n\n\n\n<p>\u4ece\u4ee5\u4e0a\u53ef\u4ee5\u770b\u5230\uff0c\u6d41\u6c60\u6cd5\u5728\u6df7\u60ac\u5242\u7684\u6eb6\u51fa\u5ea6\u7814\u7a76\u4e2d\u6709\u4e00\u5b9a\u7684\u4f18\u52bf\u3002\u4ee5\u6d41\u6c60\u6cd5\u8fdb\u884c\u7eb3\u7c73\u6df7\u60ac\u5242\u7684\u6eb6\u51fa\u5ea6\u5b9e\u9a8c\uff0c\u53ef\u4ee5\u66f4\u771f\u5b9e\u5730\u53cd\u6620\u6df7\u60ac\u5242\u7684\u91ca\u653e\u884c\u4e3a\uff0c\u63d0\u9ad8\u5b9e\u9a8c\u7ed3\u679c\u7684\u53ef\u9760\u6027\u3002\u5982\u679c\u5728\u505a\u6df7\u60ac\u5242\u7684\u6eb6\u51fa\u5b9e\u9a8c\u4e0a\u78b0\u5230\u95ee\u9898\u4e86\uff0c\u53ef\u4ee5\u5c1d\u8bd5\u4e00\u4e0b\u6d41\u6c60\u6cd5\uff0c\u6216\u8bb8\u6709\u610f\u5916\u7684\u6536\u83b7\u3002<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u6587\u732e\u5f15\u7528\uff1a<\/p>\n\n\n\n<p>[1] Rudd ND, Reibarkh M, Fang R, Mittal S, Walsh PL, Brunskill APJ, Forrest WP. Interpreting In Vitro Release Performance from Long-Acting Parenteral Nanosuspensions Using USP-4 Dissolution and Spectroscopic Techniques. Mol Pharm. 2020 May 4;17(5):1734-1747.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column is-vertically-aligned-center\" style=\"flex-basis:50%\">\n<p class=\"has-text-align-left\">\u60f3\u4e86\u89e3\u66f4\u591a\u65b9\u6848\u8be6\u60c5\uff0c<br>\u8bf7\u626b\u63cf\u4e8c\u7ef4\u7801\u8054\u7cfb\u529b\u626c\u5c0f\u52a9\u624b\u3002<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-top\" style=\"flex-basis:65%\">\n<div class=\"wp-block-columns are-vertically-aligned-center\">\n<div class=\"wp-block-column is-vertically-aligned-center\" style=\"flex-basis:100%\">\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column\" style=\"flex-basis:100%\">\n<div class=\"wp-block-image\"><figure class=\"alignleft size-medium is-resized\"><img src=\"\/wp-content\/uploads\/2022\/06\/\u529b\u626c\u5c0f\u52a9\u624b-QR-Code-300x296.png\" alt=\"\" class=\"wp-image-16373\" width=\"225\" height=\"222\" srcset=\"\/wp-content\/uploads\/2022\/06\/\u529b\u626c\u5c0f\u52a9\u624b-QR-Code-300x296.png 300w, \/wp-content\/uploads\/2022\/06\/\u529b\u626c\u5c0f\u52a9\u624b-QR-Code-768x758.png 768w, \/wp-content\/uploads\/2022\/06\/\u529b\u626c\u5c0f\u52a9\u624b-QR-Code.png 982w\" sizes=\"(max-width: 225px) 100vw, 225px\" \/><\/figure><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\"\/>\n\n\n\n<h2>\u66f4\u591a\u6587\u7ae0<\/h2>\n\n\n\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column\" style=\"flex-basis:100%\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container\">\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column\" style=\"flex-basis:100%\"><ul class=\"wp-block-latest-posts__list is-grid columns-2 has-dates wp-block-latest-posts\"><li><a href=\"https:\/\/www.nikyang.com\/news\/dissolution-nanosuspensions\/\">\u6eb6\u51fa\u5ea6\u7814\u7a76 | \u7eb3\u7c73\u6df7\u60ac\u6db2\u7684\u6eb6\u51fa\u5ea6\u6d4b\u8bd5<\/a><time datetime=\"2023-11-16T09:59:59+08:00\" class=\"wp-block-latest-posts__post-date\">2023-11-16<\/time><\/li>\n<li><a href=\"https:\/\/www.nikyang.com\/news\/event-china-pharma-university-2023\/\">\u529b\u626c\u643a\u6d41\u6c60\u6cd5\u6eb6\u51fa\u6280\u672f\u8d70\u8fdb\u8bfe\u5802<\/a><time datetime=\"2023-10-31T15:29:21+08:00\" class=\"wp-block-latest-posts__post-date\">2023-10-31<\/time><\/li>\n<li><a href=\"https:\/\/www.nikyang.com\/drug-discovery\/dissolution-on-oral-thin-films\/\">\u7a81\u7834\u6eb6\u51fa\u5c40\u9650\uff0c\u4ee5\u6d41\u6c60\u6cd5\u52a9\u529b\u53e3\u6eb6\u819c\u5236\u5242\u7814\u53d1<\/a><time datetime=\"2023-10-17T16:58:38+08:00\" class=\"wp-block-latest-posts__post-date\">2023-10-17<\/time><\/li>\n<li><a href=\"https:\/\/www.nikyang.com\/news\/event-bceia-2023\/\">BCEIA 2023 \u5b8c\u7f8e\u6536\u5b98 | \u529b\u626c\u4f01\u4e1a\u52a9\u60a8\u8fc8\u5411\u667a\u6167\u79d1\u7814\u65b0\u65f6\u4ee3\uff01<\/a><time datetime=\"2023-09-15T12:08:45+08:00\" class=\"wp-block-latest-posts__post-date\">2023-09-15<\/time><\/li>\n<\/ul>\n\n\n<p><\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7eb3\u7c73\u6df7\u60ac\u6db2\u7ed9\u836f\u7cfb\u7edf\u662f\u4e00\u79cd\u65b0\u578b\u7684\u7ed9\u836f\u7cfb\u7edf\u3002\u5c06\u836f\u7269\u505a\u6210\u7eb3\u7c73\u6df7\u60ac\u5242\u6709\u5229\u4e8e\u589e\u52a0\u836f\u7269\u6eb6\u51fa\u5ea6\u548c\u63d0\u9ad8\u751f\u7269\u5229\u7528\u5ea6\u3002\u5bf9\u4e8e\u96be\u6eb6\u6027\u836f\u7269\uff0c\u505a\u6210\u7eb3\u7c73\u6df7\u60ac\u5242\uff0c\u53ef\u6539\u5584\u5176\u4f53\u5185\u836f\u7269\u52a8\u529b\u5b66\u884c\u4e3a\uff0c\u63d0\u9ad8\u836f\u6548\u3002 \u4e0d\u540c\u5de5\u827a\u4e0b\u7684\u7eb3\u7c73\u6df7\u60ac\u5242\uff0c\u53d7\u5176\u5904\u65b9\u6210\u5206\u5dee\u5f02\u3001API\u7c92\u5f84\u5206\u5e03\u3001\u6676\u578b\u7b49\u5f71\u54cd\uff0c\u6eb6\u51fa\u884c\u4e3a\u53ef\u80fd\u6709\u5dee\u5f02\u3002 \u56e0\u6b64\uff0c\u6eb6\u51fa\u5b9e\u9a8c\u4e5f\u662f\u7eb3\u7c73\u6df7\u60ac\u5242\u7814\u7a76\u7684\u91cd\u8981\u624b\u6bb5\u3002\u90a3\u4e48\uff0c\u4e0d\u540c\u5236\u5242\u5de5\u827a\u4e0b\u5f97\u5230\u7684\u4e0d\u540c\u6279\u6b21\u7eb3\u7c73\u6df7\u60ac\u5242\uff0c\u6211\u4eec\u8be5\u5982\u4f55\u6d4b\u8bd5\u5b83\u4eec\u7684\u6eb6\u51fa\u884c\u4e3a\u662f\u5426\u6709\u660e\u663e\u5dee\u5f02\uff1f\u6eb6\u51fa\u5ea6\u6d4b\u8bd5\u5e94\u8be5\u5982\u4f55\u8fdb\u884c\uff1f \u4ece\u6df7\u60ac\u5242\u6eb6\u51fa\u5b9e\u9a8c\u7684\u89d2\u5ea6\u770b\uff0c\u4f7f\u7528\u6868\u6cd5\uff0c\u76f4\u63a5\u5c06\u6df7\u60ac\u5242\u6295\u5230\u6eb6\u51fa\u676f\u8fdb\u884c\u6eb6\u51fa\u5b9e\u9a8c\uff0c\u4f3c\u4e4e\u662f\u53ef\u884c\u7684\u65b9\u6848\u3002\u7684\u786e\uff0c\u6868\u6cd5\u4e5f\u662f\u6df7\u60ac\u5236\u5242\u4e2d\u6bd4\u8f83\u5e38\u7528\u7684\u65b9\u6cd5\uff0c\u4f46\u5f53\u4e2d\u53ef\u80fd\u5b58\u5728\u4e00\u4e9b\u95ee\u9898\uff0c\u5f71\u54cd\u5b9e\u9a8c\u7ed3\u679c\uff0c\u4e0b\u9762\u5217\u4e3e\u4e00\u4e2a\u4f8b\u5b50\uff1a \u6868\u6cd5\u00a0&#8211; \u7528\u79fb\u6db2\u67aa\u79fb\u53d6\u4e00\u5b9a\u4f53\u79ef\u7684\u6df7\u60ac\u5242\uff0c\u52a0\u5165\u6eb6\u51fa\u676f\u4e2d \u5728\u6868\u6cd5\u7684\u6eb6\u51fa\u5ea6\u5b9e\u9a8c\u4e0b\uff0c\u7eb3\u7c73\u6df7\u60ac\u5242\u7684\u6837\u54c1\u91ca\u653e\u901f\u5ea6\u8fc7\u5feb\uff0c\u65e0\u6cd5\u6bd4\u8f83\u4e0d\u540c\u6279\u6b21\u6837\u54c1\u7684\u6eb6\u51fa\u5dee\u5f02\u3002\u4ed4\u7ec6\u601d\u8003\u6868\u6cd5\u7684\u6eb6\u51fa\u5b9e\u9a8c\u8fc7\u7a0b\uff0c\u6211\u4eec\u53ef\u4ee5\u627e\u51fa\u5f53\u4e2d\u7684\u95ee\u9898\uff1a \u79fb\u6db2\u67aa\u79fb\u53d6\u7eb3\u7c73\u6df7\u60ac\u5242\uff0c6\u4e2a\u5e73\u884c\u6837\u54c1\uff0c\u52a0\u6837\u7684\u65f6\u50196\u676f\u7684\u52a0\u6837\u6709\u65f6\u95f4\u5dee\uff0c\u6837\u54c1\u7684\u6eb6\u51fa\u5728\u6df7\u60ac\u5242\u4e0e\u6eb6\u51fa\u4ecb\u8d28\u63a5\u89e6\u65f6\u5df2\u7ecf\u5f00\u59cb\uff1b \u7eb3\u7c73\u6df7\u60ac\u5242\u52a0\u5165\u5230\u6eb6\u51fa\u676f\u65f6\u7684\u9ad8\u5ea6\u3001\u4f4d\u7f6e\u53ef\u80fd\u51fa\u73b0\u5dee\u5f02\uff0c\u5f71\u54cd\u6eb6\u51fa\u7ed3\u679c\uff1b \u5c0f\u4f53\u79ef\u7684\u7eb3\u7c73\u6df7\u60ac\u5242\u4e00\u4e0b\u5b50\u52a0\u5165\u5230\u6bd4\u8f83\u5927\u4f53\u79ef\u7684\u6eb6\u51fa\u4ecb\u8d28\u4e2d\uff0c\u53ef\u80fd\u77ac\u95f4\u5df2\u5b8c\u5168\u6eb6\u51fa\uff1b \u7eb3\u7c73\u6df7\u60ac\u5242\u5206\u6563\u5728\u6eb6\u51fa\u4ecb\u8d28\u4e2d\uff0c\u53ef\u80fd\u5728\u53d6\u6837\u65f6\uff0c\u628a\u6ca1\u6eb6\u51fa\u7684\u6837\u54c1\u53d6\u8d70\uff0c\u5f71\u54cd\u6eb6\u51fa\u7ed3\u679c\u3002 \u6d41\u6c60\u6cd5\u00a0&#8211; \u6df7\u60ac\u5242\u88ab\u8f7d\u5165\u6d41\u901a\u6c60\uff0c\u4ee5\u95ed\u73af\u7cfb\u7edf\u5b8c\u6210\u5b9e\u9a8c \u9664\u4e86\u6868\u6cd5\uff0c\u5f53\u7136\u6211\u4eec\u53ef\u4ee5\u8003\u8651\u4f7f\u7528\u6d41\u6c60\u6cd5\u8fdb\u884c\u5b9e\u9a8c\u3002\u6d41\u6c60\u6cd5\u662f\u300a\u4e2d\u534e\u4eba\u6c11\u5171\u548c\u56fd\u836f\u51782020\u7248\u300b\u65b0\u589e\u7684\u65b9\u6cd5\uff0c\u56e0\u5176\u7075\u6d3b\u6027\u548c\u9002\u7528\u8303\u56f4\u5e7f\u6cdb\uff0c\u5728\u6df7\u60ac\u5242\u7684\u6eb6\u51fa\u7814\u7a76\u4e2d\u4e5f\u9002\u7528\u3002\u800c\u6d41\u6c60\u6cd5\u7684\u95ed\u73af\u7cfb\u7edf\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u7f13\u6162\u91ca\u653e\u7684\u6837\u54c1\uff0c\u8ba9\u6837\u54c1\u6162\u6162\u6eb6\u51fa\u3002 \u4ece\u6d41\u6c60\u6cd5\u7684\u7ed3\u679c\u4e2d\u770b\u51fa\uff0c\u7eb3\u7c73\u6df7\u60ac\u5242\u7f13\u6162\u6eb6\u51fa\uff0c\u4e0d\u540c\u7684\u7eb3\u7c73\u6df7\u60ac\u5242\u6eb6\u51fa\u6709\u5dee\u5f02\u3002\u76f8\u6bd4\u4e8e\u6868\u6cd5\uff0c\u6d41\u6c60\u6cd5\u6709\u4ee5\u4e0b\u4f18\u52bf\uff1a \u7eb3\u7c73\u6df7\u60ac\u5242\u88ab\u8f7d\u5165\u6d41\u901a\u6c60\u4e2d\uff0c\u52a0\u6837\u4f4d\u7f6e\u76f8\u5bf9\u56fa\u5b9a\uff1b \u7eb3\u7c73\u6df7\u60ac\u5242\u5728\u5b9e\u9a8c\u5f00\u59cb\u540e\u624d\u4e0e\u6eb6\u51fa\u4ecb\u8d28\u63a5\u89e6\uff0c\u624d\u5f00\u59cb\u6eb6\u51fa\u7684\u8fc7\u7a0b\uff1b \u7eb3\u7c73\u6df7\u60ac\u5242\u53ef\u4ee5\u88ab\u6ee4\u819c\u963b\u6321\u5728\u6d41\u901a\u6c60\u4e2d\uff0c\u6eb6\u51fa\u8fc7\u7a0b\u5728\u6d41\u901a\u6c60\u4e2d\u53d1\u751f\uff1b \u6d41\u901a\u6c60\u6c60\u5b50\u4f53\u79ef\u8f83\u5c0f\uff0c\u5e76\u4e14\u5728\u6eb6\u51fa\u539f\u7406\u4e0a\u5176\u52a8\u529b\u66f4\u6e29\u548c\uff0c\u80fd\u5f97\u5230\u8f83\u7f13\u6162\u7684\u6eb6\u51fa\u66f2\u7ebf\u3002 \u4e00\u7bc7\u53d1\u5e03\u5728Molecular Pharmaceutics\u7684\u6587\u732e[1]\uff0c\u4e5f\u5229\u7528\u6d41\u6c60\u6cd5\u8fdb\u884c\u4e86\u7eb3\u7c73\u6df7\u60ac\u5242\u7684\u4f53\u5916\u91ca\u653e\u5ea6\u7814\u7a76\u3002\u5728\u6eb6\u51fa\u8fc7\u7a0b\u4e2d\uff0c\u7eb3\u7c73\u6df7\u60ac\u5242\u88ab\u88c5\u8f7d\u5728\u6d41\u901a\u6c60\u4e2d\u7684\uff0c\u5df2\u6eb6\u51fa\u7684API\u53ef\u4ee5\u900f\u8fc7\u6ee4\u819c\u6d41\u51fa\u6d41\u901a\u6c60\uff0c\u800c\u6ca1\u6709\u6eb6\u51fa\u7684API\u5219\u88ab\u963b\u6321\u5728\u6d41\u901a\u6c60\u91cc\u7ee7\u7eed\u6eb6\u51fa\u3002 \u5bf9\u6d41\u6c60\u6cd5\u65b9\u6cd5\u8fdb\u884c\u4f18\u5316\u540e\uff0c\u53ef\u4ee5\u8fdb\u884c\u4e0d\u540c\u6837\u54c1\u7684\u6eb6\u51fa\u5b9e\u9a8c\uff0c\u6709\u6548\u5bf9\u6bd4\u6eb6\u51fa\u884c\u4e3a\u7684\u5dee\u5f02\u3002 \u4ece\u4ee5\u4e0a\u53ef\u4ee5\u770b\u5230\uff0c\u6d41\u6c60\u6cd5\u5728\u6df7\u60ac\u5242\u7684\u6eb6\u51fa\u5ea6\u7814\u7a76\u4e2d\u6709\u4e00\u5b9a\u7684\u4f18\u52bf\u3002\u4ee5\u6d41\u6c60\u6cd5\u8fdb\u884c\u7eb3\u7c73\u6df7\u60ac\u5242\u7684\u6eb6\u51fa\u5ea6\u5b9e\u9a8c\uff0c\u53ef\u4ee5\u66f4\u771f\u5b9e\u5730\u53cd\u6620\u6df7\u60ac\u5242\u7684\u91ca\u653e\u884c\u4e3a\uff0c\u63d0\u9ad8\u5b9e\u9a8c\u7ed3\u679c\u7684\u53ef\u9760\u6027\u3002\u5982\u679c\u5728\u505a\u6df7\u60ac\u5242\u7684\u6eb6\u51fa\u5b9e\u9a8c\u4e0a\u78b0\u5230\u95ee\u9898\u4e86\uff0c\u53ef\u4ee5\u5c1d\u8bd5\u4e00\u4e0b\u6d41\u6c60\u6cd5\uff0c\u6216\u8bb8\u6709\u610f\u5916\u7684\u6536\u83b7\u3002 \u6587\u732e\u5f15\u7528\uff1a [1] Rudd ND, Reibarkh M, Fang R, Mittal S, Walsh PL, Brunskill APJ, Forrest WP. Interpreting In Vitro Release Performance from Long-Acting Parenteral Nanosuspensions Using USP-4 Dissolution and Spectroscopic Techniques. Mol [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":18162,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[151,327],"tags":[102,614,629,411,610,611],"_links":{"self":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts\/18152"}],"collection":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/comments?post=18152"}],"version-history":[{"count":14,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts\/18152\/revisions"}],"predecessor-version":[{"id":18184,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts\/18152\/revisions\/18184"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/media\/18162"}],"wp:attachment":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/media?parent=18152"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/categories?post=18152"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/tags?post=18152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}