{"id":16387,"date":"2022-07-12T16:13:09","date_gmt":"2022-07-12T08:13:09","guid":{"rendered":"https:\/\/www.nikyang.com\/?p=16387"},"modified":"2022-07-13T09:59:03","modified_gmt":"2022-07-13T01:59:03","slug":"automated-solution-for-new-drug-rd","status":"publish","type":"post","link":"https:\/\/www.nikyang.com\/drug-discovery\/automated-solution-for-new-drug-rd\/","title":{"rendered":"\u65b0\u836f\u7814\u53d1\u96be\u5173 \u5982\u4f55\u4ee5\u81ea\u52a8\u5316\u6280\u672f\u653b\u514b\u969c\u788d"},"content":{"rendered":"\t\t
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\u65b0\u836f\u7814\u53d1\u8fc7\u7a0b\u4e2d\uff0c\u6837\u54c1\u524d\u5904\u7406\u4e0d\u5355\u8017\u65f6\u957f, \u4e14\u6210\u672c\u9ad8\uff0c\u5c24\u5176\u662f\u6837\u54c1\u79f0\u91cf\uff0c\u53ef\u4ee5\u8bf4\u662f\u6bcf\u4e2a\u5b9e\u9a8c\u4eba\u5458\u907f\u4e0d\u5f00\u7684\u64cd\u4f5c\uff0c\u6bcf\u6b21\u5f00\u59cb\u5b9e\u9a8c\u7684\u65f6\u5019\uff0c\u9996\u5148\u8981\u505a\u7684\u4e8b\u60c5\u5c31\u662f\u6837\u54c1\u79f0\u91cf\u3001\u8bd5\u5242\u6295\u6599\u3002<\/p>

\u79f0\u91cf\u4efb\u52a1\u770b\u4f3c\u7b80\u5355\uff0c\u4f46\u5374\u6d89\u53ca\u8bb8\u591a\u7e41\u7410\u4e14\u91cd\u590d\u7684\u6b65\u9aa4\uff0c\u6781\u5bb9\u6613\u4ea7\u751f\u4eba\u4e3a\u8bef\u5dee\u3002\u9047\u5230\u7279\u6b8a\u60c5\u51b5\uff0c\u66f4\u662f\u4f1a\u7ed9\u64cd\u4f5c\u4eba\u5458\u5e26\u6765\u4e0d\u5c0f\u7684\u6311\u6218\u3002\u4e3a\u4e86\u5e94\u5bf9\u4ee5\u4e0a\u96be\u9898\uff0c\u529b\u626c\u4f01\u4e1a\u6700\u8fd1\u5c31\u65b0\u836f\u7814\u53d1\u8bdd\u9898\uff0c\u9080\u8bf7\u4e86\u4ea7\u54c1\u7ecf\u7406\u675c\u4e16\u632f\u535a\u58eb\u4e0e\u836f\u7814\u7fa4\u7ec4\u6210\u5458\u5c55\u5f00\u4e86\u5728\u7ebf\u8ba8\u8bba\uff0c\u5e76\u603b\u7ed3\u4e86\u4ee5\u4e0b\u5185\u5bb9\uff0c\u4eca\u5929\u4e0e\u5927\u5bb6\u4e00\u540c\u5206\u4eab\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u4f20\u7edf\u52a0\u6837\u4e2d\uff0c\u6211\u4eec\u9700\u8981\u628a\u6837\u54c1\u653e\u5728\u53f0\u5f0f\u5929\u5e73\u4e0a\uff0c\u7ee7\u800c\u8fdb\u884c\u5206\u914d\uff0c\u4f46\u5982\u6b64\u7b80\u5355\u7684\u4e00\u4e2a\u4efb\u52a1\u5374\u5f80\u5f80\u662f\u5728\u7814\u53d1\u8fc7\u7a0b\u4e2d\u7684\u4e00\u4e2a\u74f6\u9888\u95ee\u9898\uff0c\u6bd4\u5982\u6837\u54c1\u6570\u91cf\u591a\u3001\u7279\u6b8a\u6837\u54c1\u00a0(\u5982: \u5fae\u91cf\u3001\u9ad8\u7c98\u5ea6\u3001\u6613\u6325\u53d1\u6837\u54c1\u7b49)\u00a0\u79f0\u91cf\u96be\uff0c\u8fb9\u53cd\u5e94\u8fb9\u52a0\u6837\u96be\u64cd\u4f5c\u7b49\u3002<\/p>

\u9488\u5bf9\u8fd9\u4e9b\u95ee\u9898\uff0c\u745e\u58eb Chemspeed<\/a> \u7814\u53d1\u4e86\u72ec\u521b\u6027\u7684\u9876\u7f6e\u5f0f\u52a0\u6837<\/strong><\/a>\u65b9\u5f0f\uff0c\u5bf9\u4f20\u7edf\u7684\u79f0\u91cf\u52a0\u6837\u65b9\u5f0f\u8fdb\u884c\u4e86\u9769\u547d\u6027\u7684\u6539\u53d8\uff0c\u4ece\u6839\u672c\u4e0a\u89e3\u51b3\u4e86\u4e0a\u9762\u63d0\u5230\u7684\u74f6\u9888\u95ee\u9898\u3002\u5982\u56fe\u6240\u793a\uff0c\u9876\u7f6e\u5f0f\u5929\u5e73\u914d\u7f6e\u5728\u5e73\u53f0\u4e0a\uff0c\u88ab\u8a89\u4e3a\u00a0\u201c\u884c\u8d70\u7684\u5929\u5e73\u201d\uff0c\u5b83\u7531\u673a\u68b0\u624b\u6293\u8d77\u3001\u79fb\u52a8\uff0c\u5e76\u5e26\u7740\u6837\u54c1\u6309\u7167\u8bbe\u5b9a\u7684\u7a0b\u5e8f\u8d70\u5230\u6307\u5b9a\u7684\u76ee\u6807\u5bb9\u5668\u4e0a\u65b9\uff0c\u7136\u540e\u4ee5\u7a0b\u5e8f\u8bbe\u5b9a\u7684\u8d28\u91cf\u8fdb\u884c\u6837\u54c1\u5206\u914d\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u6beb\u514b\u7ea7\u522b \u52a0\u6837\u8f7b\u677e<\/strong><\/h5>

\u4ecb\u4e8e 1 \u2013 2 \u6beb\u514b\u6216\u8005\u5c11\u4e8e 1 \u6beb\u514b\u7684\u6837\u54c1\uff0c\u52a0\u6837\u96be\u5ea6\u8f83\u5927\uff0cChemspeed \u8bbe\u6709\u4e24\u6b3e\u5de5\u5177\u53ef\u4ee5\u5b8c\u6210\u4efb\u52a1\u3002<\/p>

\u7b2c\u4e00\u4e2a\u662f GDU-P fd (\u89c1\u4e0b\u56fe\u4e2d\u84dd\u5708\u5904)\uff0c\u6b64\u5de5\u5177\u9002\u7528\u4e8e\u6709\u8db3\u591f\u7269\u6599\u6765\u6e90\u7684\u6837\u54c1\uff0c\u6bd4\u5982\u5b9e\u9a8c\u5ba4\u7684\u5e38\u89c4\u8bd5\u5242\u3002\u5f53\u7269\u6599\u6709\u51e0\u5341\u6216\u8005\u4e0a\u767e\u514b\u53ef\u4ee5\u7528\u65f6\uff0c\u8fd9\u79cd\u60c5\u51b5\u4e0b\u4fbf\u53ef\u4ee5\u5c06\u7269\u6599\u9884\u5148\u586b\u88c5\u5230 GDU-P fd \u7684\u7269\u6599\u7f50\u5185\u00a0(30mL)\uff0c\u7136\u540e\u901a\u8fc7 GDU-P fd \u5929\u5e73\u8fdb\u884c\u81ea\u52a8\u52a0\u6837\u3002<\/p>

\u7b2c\u4e8c\u4e2a\u5de5\u5177\u662f SWILE (\u89c1\u4e0b\u56fe\u4e2d\u84dd\u5708\u5904)\uff0c\u5b83\u53ef\u4ee5\u5b8c\u6210\u5206\u914d 100 \u5fae\u514b\u5230 10 \u6beb\u514b\u8303\u56f4\u5185\u6837\u54c1\uff0c\u5176\u5e94\u7528\u573a\u666f\u4e3b\u8981\u662f\u7269\u6599\u6709\u9650\u6216\u8005\u6837\u54c1\u7279\u522b\u73cd\u8d35\u8bd5\u5242\u6216\u6837\u54c1\u3002\u5206\u914d\u8fc7\u7a0b\u4f7f\u7528\u4e00\u6b21\u6027\u73bb\u7483\u6bdb\u7ec6\u7ba1\u5206\u914d\u5668\uff0c\u76f4\u63a5\u5230\u7269\u6599\u74f6\u91cc\u00a0(\u5982 2mL \u5c0f\u74f6\u3001\u6216 4mL \u5c0f\u74f6) \u53d6\u6837\uff0c\u7136\u540e\u5929\u5e73\u79fb\u52a8\u5230\u76ee\u6807\u5bb9\u5668\u4e0a\u65b9\u8fdb\u884c\u5206\u914d\uff0c\u5206\u914d\u8fc7\u7a0b\u65e0\u6b7b\u4f53\u79ef\uff0c\u65e0\u4ea4\u53c9\u6c61\u67d3\uff0c\u800c\u4e14\u4e0d\u9700\u8981\u5bf9\u539f\u6599\u8fdb\u884c\u5206\u88c5\u5904\u7406\uff0c\u5206\u914d\u5b8c\u6210\u540e\u539f\u6599\u74f6\u51e0\u4e4e\u4fdd\u6301\u539f\u5c01\u4e0d\u52a8\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\"Chemspeed\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u6837\u54c1\u79cd\u7c7b\u591a\u6837 \u5206\u7c7b\u5904\u7406\u4e13\u4e1a\u5316<\/strong><\/h5>

\u5728\u957f\u8fbe 20 \u591a\u5e74\u7684\u7814\u53d1\u5386\u7a0b\u4e2d\uff0c Chemspeed \u9010\u6b65\u5f00\u53d1\u4e86\u516d\u6b3e\u4e3b\u8981\u9876\u7f6e\u5f0f\u52a0\u6837\u5de5\u5177\uff0c\u53ef\u4ee5\u8986\u76d6\u5728\u5b9e\u9a8c\u8fc7\u7a0b\u4e2d\u5927\u591a\u6570\u6837\u54c1\u3002\u56fe\u4e2d\u5de6\u4e09\u6b3e\u662f\u9488\u5bf9\u56fa\u4f53\u6837\u54c1\u52a0\u6837\u7684\u5de5\u5177\uff0c\u5b83\u4eec\u53ef\u4ee5\u5b8c\u6210\u5355\u6b21\u52a0\u6837 1 \u6beb\u514b\u4ee5\u4e0b\u5230 100 \u514b\u8303\u56f4\u5185\u7684\u56fa\u4f53\u6837\u54c1\u52a0\u6837\u4efb\u52a1\u00a0(\u5982\u7c89\u672b\u3001\u9897\u7c92\u72b6\u7684\u5316\u5408\u7269);\u56fe\u4e2d\u53f3\u4e09\u6b3e\u662f\u9488\u5bf9\u6db2\u4f53\u5316\u5408\u7269\u8fdb\u884c\u5206\u914d\u7684\uff0c\u5176\u4e2d GDU-V \u662f\u5bf9\u6db2\u4f53\u6309\u8d28\u91cf\u8fdb\u884c\u5206\u914d\u7684\u5de5\u5177\uff0c\u800c GDU-HV \u662f\u9488\u5bf9\u9ad8\u7c98\u5ea6\u00a0(\u5982\u7518\u6cb9\u3001\u818f\u72b6\u7269)\u00a0\u5316\u5408\u7269\u7684\u52a0\u6837\u5de5\u5177\u3002\u5bf9\u4e8e\u6beb\u514b\u7ea7\u522b\u6216\u8005\u6beb\u514b\u4ee5\u4e0b\u7684\u6db2\u4f53\u5316\u5408\u7269\uff0cSWIP \u53ef\u4ee5\u8f7b\u677e\u5e94\u4ed8\u3002\u7531\u4e8e\u5b83\u7684\u52a0\u6837\u8fc7\u7a0b\u9700\u8981\u7528\u6bdb\u7ec6\u7ba1\u8fdb\u884c\u6cbe\u53d6\uff0c\u56e0\u6b64 SWIP \u9002\u7528\u4e8e\u7c98\u7a20\u72b6\u5316\u5408\u7269\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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