{"id":16362,"date":"2022-06-27T14:18:27","date_gmt":"2022-06-27T06:18:27","guid":{"rendered":"https:\/\/www.nikyang.com\/?p=16362"},"modified":"2022-06-27T14:20:47","modified_gmt":"2022-06-27T06:20:47","slug":"new-drug-rd-technlogy","status":"publish","type":"post","link":"https:\/\/www.nikyang.com\/drug-discovery\/new-drug-rd-technlogy\/","title":{"rendered":"\u642d\u4e58\u5b9e\u9a8c\u5ba4\u8bbe\u5907\u667a\u80fd\u5316\u5feb\u8f66\uff0c\u8ba9\u65b0\u836f\u7814\u53d1\u4e00\u8def\u7545\u901a"},"content":{"rendered":"\t\t
\u5341\u56db\u4e94\u533b\u836f\u5de5\u4e1a\u53d1\u5c55\u89c4\u5212\u6307\u5bfc\u601d\u60f3\u9996\u6b21\u6307\u51fa\uff0c\u5168\u9762\u63d0\u9ad8\u533b\u836f\u4ea7\u4e1a\u94fe\u73b0\u4ee3\u5316\u6c34\u5e73\uff0c\u5b9e\u73b0\u4f9b\u5e94\u94fe\u7a33\u5b9a\u53ef\u63a7\uff0c\u52a0\u5feb\u521b\u65b0\u9a71\u52a8\u53d1\u5c55\u8f6c\u578b\u3002\u914d\u5408\u5404\u5730\u65b9\u653f\u5e9c\u76f8\u7ee7\u51fa\u53f0\u76f8\u5173\u5229\u597d\u653f\u7b56\uff0c\u4f7f\u5b9e\u9a8c\u5ba4\u667a\u80fd\u5316\u4e0e\u81ea\u52a8\u5316\u8d8b\u52bf\u52bf\u4e0d\u53ef\u6321\u3002\u65b0\u836f\u7814\u53d1\u51ed\u7740\u8fd9\u4e2a\u4f18\u52bf\uff0c\u4e5f\u5c06\u52a0\u5feb\u4ee5\u9ad8\u7aef\u6280\u672f\u63a8\u52a8\u884c\u4e1a\u53d1\u5c55\u7684\u6b65\u4f10\u3002<\/p>
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1\/3\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t \u800c\u4e14\u6837\u54c1\u5236\u5907\u8fc7\u7a0b\u4e2d\u6d89\u53ca\u5927\u91cf\u7e41\u7410\u7684\u64cd\u4f5c\u548c\u91cd\u590d\u7684\u6b65\u9aa4\uff0c\u6781\u5bb9\u6613\u5e26\u5165\u4eba\u4e3a\u8bef\u5dee\uff0c\u800c\u4e14\u591a\u6570\u60c5\u51b5\u4e0b\u64cd\u4f5c\u4eba\u5458\u5e76\u4e0d\u81ea\u77e5\u8bef\u5dee\u7684\u5f15\u5165\uff0c\u7531\u6b64\u9020\u6210\u7684\u65e0\u6548\u5b9e\u9a8c\u751a\u81f3\u662f\u5931\u8d25\u5b9e\u9a8c\u4e0d\u80dc\u679a\u4e3e\u3002<\/p><\/section> \u76ee\u524d\u6765\u770b\uff0c\u81ea\u52a8\u5316\u8fc7\u7a0b\u662f\u6253\u7834\u6837\u54c1\u5236\u5907\u74f6\u9888\u7684\u6700\u597d\u89e3\u51b3\u65b9\u6848\u3002\u9996\u5148\uff0c\u81ea\u52a8\u5316\u6837\u54c1\u5236\u5907\u53ef\u4ee5\u5c06\u7814\u53d1\u4eba\u5458\u4ece\u91cd\u590d\u6027\u7684\u52b3\u52a8\u4e2d\u89e3\u653e\u51fa\u6765\uff0c\u5c06\u66f4\u591a\u7684\u7cbe\u529b\u96c6\u4e2d\u5230\u65b9\u6848\u8bbe\u8ba1\u3001\u7ed3\u679c\u5206\u6790\u7b49\u7814\u53d1\u7684\u672c\u8d28\u5de5\u4f5c\u4e0a\uff1b\u53e6\u4e00\u65b9\u9762\uff0c\u81ea\u52a8\u5316\u8fc7\u7a0b\u53ef\u4ee5\u4ece\u6839\u672c\u4e0a\u89e3\u51b3\u4eba\u4e3a\u8bef\u5dee\u7684\u95ee\u9898\uff0c\u6570\u636e\u7edd\u5bf9\u5ba2\u89c2\u53ef\u4fe1\uff0c\u800c\u4e14\u53ef\u4ee5\u6570\u636e\u6eaf\u6e90\u3002<\/p><\/section>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t \u8fd1\u5e74\u6765\uff0c\u81ea\u52a8\u5316\u5b9e\u9a8c\u6280\u672f\u65e5\u76ca\u6210\u719f\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u836f\u4f01\u613f\u610f\u6295\u653e\u8d44\u6e90\u5728\u81ea\u52a8\u5316\u53ca\u667a\u80fd\u5316\u89e3\u51b3\u65b9\u6848\u4e0a\uff0c\u4ee5\u9ad8\u6548\u7684\u7cbe\u51c6\u52a0\u6837\u8bbe\u5907\u6765\u52a0\u5feb\u65b0\u836f\u7814\u53d1\u7684\u6b65\u4f10\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t \u5e02\u573a\u4e2d\u4f17\u591a\u7684\u81ea\u52a8\u5316\u89e3\u51b3\u65b9\u6848\u4e2d\uff0c\u745e\u58eb\u7684 Chemspeed \u81ea\u52a8\u5316\u52a0\u6837\u6280\u672f\uff0c\u5bf9\u4f20\u7edf\u7684\u79f0\u91cf\u52a0\u6837\u65b9\u5f0f\u8fdb\u884c\u4e86\u98a0\u8986\u6027\u7684\u53d8\u9769\uff0c\u5c06\u4f20\u7edf\u7684\u52a0\u6837\u6548\u7387\u63d0\u9ad8\u4e86\u5341\u500d\u4ee5\u4e0a\uff0c\u8d62\u5f97\u4e86\u5982\u8bfa\u534e\u3001\u9ed8\u514b\u3001\u62dc\u5c14\u3001\u963f\u65af\u5229\u5eb7\u7b49\u77e5\u540d\u836f\u4f01\u7684\u9752\u7750\uff0c\u5e76\u5e7f\u53d7\u8d5e\u8a89\u30101\u3011\uff0c\u6210\u4e3a\u5176\u6837\u54c1\u5236\u5907\u4e3b\u8981\u65b9\u6848\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t \u6b64\u5916\uff0cChemspeed \u7684\u81ea\u52a8\u5316\u89e3\u51b3\u65b9\u6848\u4e5f\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5b66\u672f\u7814\u7a76\u9886\u57df\uff0c\u5982 2021 \u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u83b7\u5f97\u8005 David MacMillan\uff0c\u65e9\u5728\u5341\u51e0\u5e74\u524d\uff0cChemspeed \u5c31\u4e0e\u5176\u5efa\u7acb\u4e86\u5408\u4f5c\u5173\u7cfb\uff0c\u5176\u65e9\u5728 2011 \u5e74\u5728 Science \u4e0a\u53d1\u8868\u9ad8\u901a\u91cf\u5149\u50ac\u5316\u7684\u7814\u7a76\u8bba\u6587\u4e2d\u5c31\u66fe\u4f7f\u7528 Chemspeed \u7684\u81ea\u52a8\u52a0\u6837\u65b9\u6848\u30102\u3011\uff0c\u5e2e\u52a9\u5176\u63d0\u9ad8\u5b9e\u9a8c\u6548\u7387\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t Chemspeed \u72ec\u5bb6\u4e13\u5229\u7684\u7ec4\u4ef6\u00a0\u2014\u00a0\u9876\u7f6e\u5f0f\u79f0\u91cd\u5206\u914d\u5de5\u5177 (GDU) \u98a0\u8986\u4f20\u7edf\u7684\u79f0\u91cf\u5206\u914d\u6a21\u5f0f\uff0c\u521b\u9020\u6027\u7684\u4f7f\u7528\u8fb9\u79f0\u91cd\u8fb9\u52a0\u6837\u7684\u65b9\u5f0f\uff0c\u5bf9\u4f4e\u7c98\u5ea6\u6db2\u4f53\u3001\u9ad8\u7c98\u5ea6\u6db2\u4f53\u3001\u5fae\u91cf\u6db2\u4f53\u3001\u5927\u91cf\u56fa\u4f53\u3001\u5fae\u91cf\u56fa\u4f53\u7b49\u8fdb\u884c\u81ea\u52a8\u5316\u5206\u914d\uff0c\u5b8c\u7f8e\u89e3\u51b3\u73b0\u6709\u6837\u54c1\u5236\u5907\u4e2d\u7684\u74f6\u9888\u95ee\u9898\u3002\u81ea\u52a8\u52a0\u6837\u6280\u672f\u4e0d\u4ec5\u5c06\u6280\u672f\u4eba\u5458\u4ece\u91cd\u590d\u6027\u64cd\u4f5c\u4e2d\u89e3\u653e\u51fa\u6765\uff0c\u66f4\u91cd\u8981\u7684\u662f\u907f\u514d\u4e86\u4eba\u4e3a\u8bef\u5dee\u7684\u53d1\u751f\uff0c\u6781\u5927\u5730\u63d0\u9ad8\u4e86\u5b9e\u9a8c\u7684\u91cd\u590d\u6027\u548c\u53ef\u9760\u6027\uff0c\u8ba9\u65b0\u836f\u5f00\u53d1\u901f\u5ea6\u548c\u8d28\u91cf\u8fc8\u4e0a\u66f4\u9ad8\u7684\u53f0\u9636\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t \u30101\u3011\u90e8\u5206\u7528\u6237\u5bf9 Chemspeed \u81ea\u52a8\u5316\u52a0\u6837\u6280\u672f\u7684\u8bc4\u4ef7<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t \u30102\u3011David W. C. MacMillan,\u00a0et al.\u00a0 Science,\u00a02011, 334, 1114.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t \u7ed3\u5408\u4ee5\u4e0a Chemspeed \u72ec\u6709\u7684\u9876\u7f6e\u5f0f\u79f0\u91cd\u5206\u914d\u5de5\u5177 (GDU)\uff0c\u9996\u5ea6\u63a8\u51fa\u7d27\u51d1\u578b\u7684\u81ea\u52a8\u5316\u56fa\u4f53\u7c89\u672b\u52a0\u6837\u65b9\u6848 \u2014 Chemspeed Crystal Powderdose \u548c Crystal Swile\u3002\u4e24\u8005\u5206\u522b\u662f\u9488\u5bf9\u56fa\u4f53\u53ca\u7cbe\u7ec6\u7c89\u672b\u800c\u8bbe\uff0c\u62e5\u6709\u6781\u9ad8\u7cbe\u51c6\u5ea6 (0.01mg)\u3002Crystal Swile \u62e5\u6709 5 \u4e2a\u539f\u6599\u74f6\uff0c\u52a0\u6837\u8303\u56f4\u5728 0.1 – 0.5mg\uff0c\u800c Crystal Powderdose \u5219\u62e5\u6709 7 \u4e2a\u6837\u54c1\u50a8\u5b58\u7f50\uff0c\u52a0\u6837\u8303\u56f4\u5728 1mg -20g \u4e4b\u95f4\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t \u673a\u8eab\u8f7b\u5de7\u7684 Crystal \u7cfb\u5217\uff0c\u4f53\u79ef\u5c3a\u5bf8\u7ea6\u4e3a 45cm (\u957f) x 54cm (\u5bbd) x 92cm (\u9ad8)\uff0c\u53ef\u540c\u65f6\u5c06\u5929\u5e73\u3001\u673a\u68b0\u81c2\u3001\u6837\u54c1\u50a8\u5b58\u7f50\u3001\u591a\u5b54\u677f\u548c\u591a\u89c4\u683c\u5c0f\u74f6\u653e\u7f6e\u67b6\u7b49\u96c6\u6210\u5728\u4e00\u4e2a\u5c0f\u5de7\u5e73\u53f0\uff0c\u8fdb\u4e00\u6b65\u8282\u7701\u5b9e\u9a8c\u5ba4\u7a7a\u95f4\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\u8fce\u5408\u5e02\u573a , \u63a8\u51fa\u65b0\u4e00\u4ee3\u5168\u81ea\u52a8\u56fa\u4f53\u7c89\u672b\u52a0\u6837\u89e3\u51b3\u65b9\u6848<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\u529f\u80fd\u5f3a\uff0c\u4f53\u79ef\u5c0f\uff0c\u52a0\u6837\u6ca1\u70e6\u607c<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t