{"id":16362,"date":"2022-06-27T14:18:27","date_gmt":"2022-06-27T06:18:27","guid":{"rendered":"https:\/\/www.nikyang.com\/?p=16362"},"modified":"2022-06-27T14:20:47","modified_gmt":"2022-06-27T06:20:47","slug":"new-drug-rd-technlogy","status":"publish","type":"post","link":"https:\/\/www.nikyang.com\/drug-discovery\/new-drug-rd-technlogy\/","title":{"rendered":"\u642d\u4e58\u5b9e\u9a8c\u5ba4\u8bbe\u5907\u667a\u80fd\u5316\u5feb\u8f66\uff0c\u8ba9\u65b0\u836f\u7814\u53d1\u4e00\u8def\u7545\u901a"},"content":{"rendered":"\t\t
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\u6b64\u5916\uff0cChemspeed \u7684\u81ea\u52a8\u5316\u89e3\u51b3\u65b9\u6848\u4e5f\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5b66\u672f\u7814\u7a76\u9886\u57df\uff0c\u5982 2021 \u5e74\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u83b7\u5f97\u8005 David MacMillan\uff0c\u65e9\u5728\u5341\u51e0\u5e74\u524d\uff0cChemspeed \u5c31\u4e0e\u5176\u5efa\u7acb\u4e86\u5408\u4f5c\u5173\u7cfb\uff0c\u5176\u65e9\u5728 2011 \u5e74\u5728 Science \u4e0a\u53d1\u8868\u9ad8\u901a\u91cf\u5149\u50ac\u5316\u7684\u7814\u7a76\u8bba\u6587\u4e2d\u5c31\u66fe\u4f7f\u7528 Chemspeed \u7684\u81ea\u52a8\u52a0\u6837\u65b9\u6848\u30102\u3011\uff0c\u5e2e\u52a9\u5176\u63d0\u9ad8\u5b9e\u9a8c\u6548\u7387\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Chemspeed \u72ec\u5bb6\u4e13\u5229\u7684\u7ec4\u4ef6\u00a0\u2014\u00a0\u9876\u7f6e\u5f0f\u79f0\u91cd\u5206\u914d\u5de5\u5177 (GDU) \u98a0\u8986\u4f20\u7edf\u7684\u79f0\u91cf\u5206\u914d\u6a21\u5f0f\uff0c\u521b\u9020\u6027\u7684\u4f7f\u7528\u8fb9\u79f0\u91cd\u8fb9\u52a0\u6837\u7684\u65b9\u5f0f\uff0c\u5bf9\u4f4e\u7c98\u5ea6\u6db2\u4f53\u3001\u9ad8\u7c98\u5ea6\u6db2\u4f53\u3001\u5fae\u91cf\u6db2\u4f53\u3001\u5927\u91cf\u56fa\u4f53\u3001\u5fae\u91cf\u56fa\u4f53\u7b49\u8fdb\u884c\u81ea\u52a8\u5316\u5206\u914d\uff0c\u5b8c\u7f8e\u89e3\u51b3\u73b0\u6709\u6837\u54c1\u5236\u5907\u4e2d\u7684\u74f6\u9888\u95ee\u9898\u3002\u81ea\u52a8\u52a0\u6837\u6280\u672f\u4e0d\u4ec5\u5c06\u6280\u672f\u4eba\u5458\u4ece\u91cd\u590d\u6027\u64cd\u4f5c\u4e2d\u89e3\u653e\u51fa\u6765\uff0c\u66f4\u91cd\u8981\u7684\u662f\u907f\u514d\u4e86\u4eba\u4e3a\u8bef\u5dee\u7684\u53d1\u751f\uff0c\u6781\u5927\u5730\u63d0\u9ad8\u4e86\u5b9e\u9a8c\u7684\u91cd\u590d\u6027\u548c\u53ef\u9760\u6027\uff0c\u8ba9\u65b0\u836f\u5f00\u53d1\u901f\u5ea6\u548c\u8d28\u91cf\u8fc8\u4e0a\u66f4\u9ad8\u7684\u53f0\u9636\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u30101\u3011\u90e8\u5206\u7528\u6237\u5bf9 Chemspeed \u81ea\u52a8\u5316\u52a0\u6837\u6280\u672f\u7684\u8bc4\u4ef7<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\"... best solid dispensing technology ...\u201d<\/div>\n\t\t\t\n\t\t\t\t\t\t
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--- Bayer CropScience<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u201c\u2026 the only fully integrated and automated workstation for reaction preparation, synthesis (ambient pressure, pressure up to 100bar), work up, purification, analysis, and output to storage vials \/ plates.\u201d<\/div>\n\t\t\t\n\t\t\t\t\t\t
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--- Bayer AG, Research & Development, Pharmaceuticals<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u201c\u2026 the only true liquid phase and solid phase workstation \u2026\u201d<\/div>\n\t\t\t\n\t\t\t\t\t\t
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--- Abbott<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\"Chemspeed's robotic platform - CATSCREEN 96 - did pay off itself within 6 months! We do screens with wider parameter space, greater control and better quality than if we would outsource the work to several companies.\" <\/div>\n\t\t\t\n\t\t\t\t\t\t
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--- AstraZeneca<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u30102\u3011David W. C. MacMillan,\u00a0et al.\u00a0 Science,\u00a02011, 334, 1114.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u201cBy using a high-throughput, automated workflow and evaluating a large number of random reactions, we have discovered a photoredox-catalyzed C\u2013H arylation reaction for the construction of benzylic amines, an important structural motif within pharmaceutical compounds that is not readily accessed via simple substrates.\u201d<\/div>\n\t\t\t\n\t\t\t\t\t\t
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--- David W. C. MacMillan<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u8fce\u5408\u5e02\u573a , \u63a8\u51fa\u65b0\u4e00\u4ee3\u5168\u81ea\u52a8\u56fa\u4f53\u7c89\u672b\u52a0\u6837\u89e3\u51b3\u65b9\u6848<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u529f\u80fd\u5f3a\uff0c\u4f53\u79ef\u5c0f\uff0c\u52a0\u6837\u6ca1\u70e6\u607c<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u7ed3\u5408\u4ee5\u4e0a Chemspeed \u72ec\u6709\u7684\u9876\u7f6e\u5f0f\u79f0\u91cd\u5206\u914d\u5de5\u5177 (GDU)\uff0c\u9996\u5ea6\u63a8\u51fa\u7d27\u51d1\u578b\u7684\u81ea\u52a8\u5316\u56fa\u4f53\u7c89\u672b\u52a0\u6837\u65b9\u6848 \u2014 Chemspeed Crystal Powderdose \u548c Crystal Swile\u3002\u4e24\u8005\u5206\u522b\u662f\u9488\u5bf9\u56fa\u4f53\u53ca\u7cbe\u7ec6\u7c89\u672b\u800c\u8bbe\uff0c\u62e5\u6709\u6781\u9ad8\u7cbe\u51c6\u5ea6 (0.01mg)\u3002Crystal Swile \u62e5\u6709 5 \u4e2a\u539f\u6599\u74f6\uff0c\u52a0\u6837\u8303\u56f4\u5728 0.1 – 0.5mg\uff0c\u800c Crystal Powderdose \u5219\u62e5\u6709 7 \u4e2a\u6837\u54c1\u50a8\u5b58\u7f50\uff0c\u52a0\u6837\u8303\u56f4\u5728 1mg -20g \u4e4b\u95f4\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u673a\u8eab\u8f7b\u5de7\u7684 Crystal \u7cfb\u5217\uff0c\u4f53\u79ef\u5c3a\u5bf8\u7ea6\u4e3a 45cm (\u957f) x 54cm (\u5bbd) x 92cm (\u9ad8)\uff0c\u53ef\u540c\u65f6\u5c06\u5929\u5e73\u3001\u673a\u68b0\u81c2\u3001\u6837\u54c1\u50a8\u5b58\u7f50\u3001\u591a\u5b54\u677f\u548c\u591a\u89c4\u683c\u5c0f\u74f6\u653e\u7f6e\u67b6\u7b49\u96c6\u6210\u5728\u4e00\u4e2a\u5c0f\u5de7\u5e73\u53f0\uff0c\u8fdb\u4e00\u6b65\u8282\u7701\u5b9e\u9a8c\u5ba4\u7a7a\u95f4\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u7ba1\u7406\u4fe1\u606f\u66f4\u8f7b\u6613 \u8fc8\u5411\u667a\u80fd\u5316\u64cd\u4f5c<\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Chemspeed Crystal \u7684\u8f6f\u4ef6\u7cfb\u7edf\u652f\u6301\u79bb\u7ebf\u6837\u54c1\u5236\u5907\u4efb\u52a1\uff0c\u53ef\u5b9e\u73b0\u65e0\u4eba\u503c\u5b88\uff0c\u5e76\u80fd\u591f\u5feb\u901f\u6267\u884c\u3001\u76d1\u63a7\u3001\u81ea\u52a8\u8bb0\u5f55\u6570\u636e\uff0c\u5b9e\u73b0\u4fe1\u606f\u5316\u7ba1\u7406\uff0c\u4e3a\u672a\u6765\u667a\u80fd\u5316\u64cd\u4f5c\u505a\u597d\u51c6\u5907\u3002\u5bf9\u4e8e\u5b9e\u9a8c\u4eba\u5458\u6765\u8bf4\uff0c\u62e5\u6709\u8fd9\u6837\u7684\u9ad8\u79d1\u6280\uff0c\u662f\u4ee4\u4eba\u60ca\u559c\u7684\u798f\u5229\u3002<\/p><\/section>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\"\"\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\u5728\u653f\u7b56\u5229\u597d\u7684\u5927\u80cc\u666f\u4e0b\uff0c\u4e2d\u56fd\u5236\u836f\u4f01\u4e1a\u6b63\u5904\u5728\u84ec\u52c3\u53d1\u5c55\u7684\u5173\u952e\u9636\u6bb5\uff0c\u5e02\u573a\u5e94\u7528\u9010\u6e10\u6253\u5f00\uff0c\u9ad8\u7aef\u79d1\u5b66\u4eea\u5668\u7684\u5e02\u573a\u9700\u6c42\u9010\u6e10\u63d0\u5347\u3002\u672a\u6765\uff0c\u81ea\u52a8\u5316\u53ca\u667a\u80fd\u5316\u6280\u672f\u5c06\u8d8a\u6765\u8d8a\u6210\u4e3a\u4eba\u7c7b\u7684\u5e2e\u624b\uff0c\u7ed9\u7814\u53d1\u4eba\u5458\u5e26\u6765\u4fbf\u6377\u3002Chemspeed Crystal \u7cfb\u5217\u4ece\u7814\u53d1\u5230\u8d28\u63a7\u53cc\u91cd\u62a4\u822a\uff0c\u5728\u5b9e\u9a8c\u5ba4\u81ea\u52a8\u5316\u9886\u57df\u7ed9\u5ba2\u6237\u5e26\u6765\u5168\u65b0\u7684\u5347\u7ea7\u4f53\u9a8c\u3002<\/p>

\u529b\u626c\u4f01\u4e1a\u51ed\u7740\u591a\u5e74\u5728\u5b9e\u9a8c\u5ba4\u81ea\u52a8\u5316\u7684\u7ecf\u9a8c\uff0c\u5f15\u5165 Chemspeed Crystal \u5168\u81ea\u52a8\u56fa\u4f53\u7c89\u672b\u52a0\u6837\u89e3\u51b3\u65b9\u6848\uff0c\u52a9\u529b\u56fd\u5185\u836f\u4f01\u4e5f\u80fd\u642d\u4e58\u667a\u80fd\u5316 \u201c\u5feb\u8f66\u201d\uff0c\u964d\u4f4e\u65b0\u836f\u7814\u53d1\u73af\u8282\u6240\u9762\u5bf9\u7684\u5404\u79cd\u98ce\u9669\uff0c\u5728\u836f\u7269\u521b\u65b0\u7684\u9053\u8def\u4e0a\u4e00\u8def\u524d\u884c\u3002<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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