{"id":15641,"date":"2022-03-02T12:16:25","date_gmt":"2022-03-02T04:16:25","guid":{"rendered":"https:\/\/www.nikyang.com\/?p=15641"},"modified":"2022-03-02T13:59:36","modified_gmt":"2022-03-02T05:59:36","slug":"hptlc-mrna-case-study","status":"publish","type":"post","link":"https:\/\/www.nikyang.com\/tlc\/hptlc-mrna-case-study\/","title":{"rendered":"\u5e94\u7528\u6848\u4f8b | \u4ee5 mRNA \u75ab\u82d7\u4e3a\u4f8b\uff0c\u8102\u8d28\u5236\u5242\u8d28\u63a7\uff0c\u5355\u4e2a\u6837\u54c1\u4ec5\u9700 4 \u5206\u949f\uff01"},"content":{"rendered":"\n<p>\u5728\u4eba\u7c7b\u8fce\u6218\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e (Corona Virus Disease 2019, COVID-19) \u75ab\u60c5\u4e2d\uff0cmRNA \u75ab\u82d7\u7684\u4f5c\u7528\u6bcb\u5eb8\u7f6e\u7591\uff0c\u5b83\u6709\u6548\u9884\u9632\u548c\u63a7\u5236\u4e86\u75c5\u6bd2\u4f20\u64ad\u3002<\/p>\n\n\n\n<p>mRNA \u75ab\u82d7\u5177\u6709\u7814\u53d1\u5468\u671f\u77ed\u3001\u514d\u75ab\u539f\u6027\u5f3a\u3001\u5bf9\u75c5\u539f\u4f53\u53d8\u5f02\u53cd\u5e94\u8fc5\u901f\u548c\u6613\u4e8e\u6279\u91cf\u751f\u4ea7\u7b49\u8bf8\u591a\u4f18\u70b9\u3002\u4f46\u5728\u7814\u53d1\u8fc7\u7a0b\u4e2d\uff0c\u5b83\u4e5f\u5b58\u5728\u7740\u4e1a\u5185\u4f17\u6240\u5468\u77e5\u7684<strong>\u4e24\u5927\u6280\u672f\u96be\u70b9\uff1a\u4e00\u662f\u5206\u5b50\u8bbe\u8ba1\uff0c\u4e8c\u662f\u9012\u9001\u7cfb\u7edf\u3002<\/strong><\/p>\n\n\n\n<p>\u76ee\u524d\u666e\u904d\u91c7\u7528\u8102\u8d28\u7eb3\u7c73\u7c92 (LNP) \u5c01\u88c5 mRNA \u75ab\u82d7\u7684\u8106\u5f31\u5206\u5b50\u3002LNP \u5c01\u88c5\u9012\u9001\u9776\u5411\u6027\u5f3a\u3001\u5305\u5c01\u7387\u9ad8\u3001\u7ec6\u80de\u4eb2\u548c\u6027\u597d\uff0c\u53ef\u4ee5\u9632\u6b62 mRNA \u75ab\u82d7\u7684\u8106\u5f31\u5206\u5b50\u5728\u5230\u8fbe\u4f5c\u7528\u9776\u6807\u4e4b\u524d\u88ab\u6d88\u5316\u6216\u5207\u788e\u3002<\/p>\n\n\n\n<p><strong>\u203b \u672c\u6587\u6240\u5c55\u793a\u7684\u6848\u4f8b\u662f\u901a\u8fc7\u9ad8\u6548\u8584\u5c42\u8272\u8c31\u6280\u672f (HPTLC)\uff0c\u5bf9\u8102\u8d28\u5236\u5242\u914d\u65b9\u7ec4\u6210\u8fdb\u884c\u5feb\u901f\u3001\u7b80\u4fbf\u548c\u7a33\u5065\u7684\u9ad8\u901a\u91cf\u5206\u6790\u68c0\u6d4b\uff0c\u53ef\u5e7f\u6cdb\u5e94\u7528\u4e8e\u8102\u8d28\u5236\u5242\u7684\u914d\u65b9\u7b5b\u9009\u4ee5\u53ca\u8d28\u91cf\u63a7\u5236\u7b49\u7814\u7a76\u3002<\/strong><\/p>\n\n\n\n<h2><strong><span class=\"has-inline-color has-vivid-cyan-blue-color\">mRNA \u75ab\u82d7\u5236\u5242\u4e2d\u8102\u8d28\u6210\u5206\u7684\u5206\u6790<\/span><\/strong><\/h2>\n\n\n\n<p>\u9633\u79bb\u5b50\u8102\u8d28\u4f53\u53ef\u4e0e mRNA \u5f62\u6210\u590d\u5408\u7269\uff0c\u4ece\u800c\u6709\u6548\u8fdb\u5165\u7ec6\u80de\u8fdb\u884c\u8f6c\u67d3\u3002\u901a\u5e38\u7684\u9633\u79bb\u5b50\u8102\u8d28\u4f53\u5904\u65b9\u4e2d\u9700\u542b\u6709\u9633\u79bb\u5b50\u8102\u8d28\u3001\u80c6\u56fa\u9187\u3001\u4e2d\u6027\u52a9\u78f7\u8102\u4ee5\u53ca PEG \u5316\u78f7\u8102\u7b49\u3002<\/p>\n\n\n\n<p>\u6848\u4f8b\u4e2d\u9009\u62e9\u4e86 DOPS\u3001DOPE\u3001DOTAP \u7b49\u5e38\u7528\u7684\u8f85\u52a9\u8102\u8d28\u548c\u9633\u79bb\u5b50\u8102\u8d28\u4f5c\u4e3a\u5bf9\u7167\u54c1\uff0c\u6765\u5206\u6790\u68c0\u6d4b\u8102\u8d28\u5236\u5242\u914d\u65b9\u7684\u6210\u5206\u7ec4\u6210\u3002<\/p>\n\n\n\n<p>\u4ee5 mRNA \u75ab\u82d7\u5236\u5242\u4e2d\u8102\u8d28\u6210\u5206\u7684\u5206\u6790\u4e3a\u4f8b\uff0cHPTLC \u5206\u6790\u8272\u8c31\u56fe\u7ed3\u679c\u5982\u4e0b\u6240\u793a\uff1a<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img width=\"1024\" height=\"388\" src=\"\/wp-content\/uploads\/2022\/03\/HPTLC-chromatograms-at-UV-366-nm-1024x388.png\" alt=\"mRNA \u75ab\u82d7\u5236\u5242\u4e2d\u8102\u8d28\u6210\u5206\u7684 HPTLC \u5206\u6790\u8272\u8c31\u56fe\u7ed3\u679c\" class=\"wp-image-15646\" srcset=\"\/wp-content\/uploads\/2022\/03\/HPTLC-chromatograms-at-UV-366-nm-1024x388.png 1024w, \/wp-content\/uploads\/2022\/03\/HPTLC-chromatograms-at-UV-366-nm-300x114.png 300w, \/wp-content\/uploads\/2022\/03\/HPTLC-chromatograms-at-UV-366-nm-768x291.png 768w, \/wp-content\/uploads\/2022\/03\/HPTLC-chromatograms-at-UV-366-nm.png 1469w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p><sub>\u6ce8\uff1a\u6837\u54c1\u4ece\u5de6\u81f3\u53f3\u4f9d\u6b21\u4e3a DOPS (\u4e8c\u6cb9\u9170\u57fa\u78f7\u8102\u9170\u4e1d\u6c28\u9178)\uff0clyso-DOPE (\u6eb6\u8840-\u4e8c\u6cb9\u9170\u78f7\u8102\u9170\u4e59\u9187\u80fa)\uff0cDOTAP (\u6eb4\u5316\u4e09\u7532\u57fa-2, 3-\u4e8c\u6cb9\u9170\u6c27\u57fa\u4e19\u57fa\u94f5)\uff0cDOPE (\u4e8c\u6cb9\u9170\u78f7\u8102\u9170\u4e59\u9187\u80fa)\uff0cDOTMA (\u6c2f\u5316\u4e09\u7532\u57fa-2, 3-\u4e8c\u6cb9\u70ef\u6c27\u57fa\u4e19\u57fa\u94f5)\uff0cDODMA (1,2-\u4e8c\u6cb9\u9187-3-\u4e8c\u7532\u57fa\u6c28\u57fa-\u4e19\u70f7)\uff0c\u6cb9\u9178\uff0c\u80c6\u56fa\u9187<\/sub><\/p>\n\n\n\n<p>\u5e94\u7528\u4e0a\u8ff0\u8272\u8c31\u6761\u4ef6\u5bf9\u672a\u77e5\u7ec4\u6210\u7684\u5236\u5242\u6837\u54c1\u8fdb\u884c HPTLC \u5206\u79bb\uff0c\u53ef\u6839\u636e\u8272\u8c31\u7ed3\u679c\u63a8\u6d4b\u5236\u5242\u914d\u65b9\u7ec4\u6210\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-thumbnail is-resized\"><img src=\"\/wp-content\/uploads\/2022\/03\/HPTLC0result-dops-dope-dodma-150x150.png\" alt=\"\u6839\u636e HPTLC \u5206\u79bb\u8272\u8c31\u7ed3\u679c\uff0c\u53ef\u63a8\u6d4b\u672a\u77e5\u7ec4\u6210\u7684\u5236\u5242\u6837\u54c1\u914d\u65b9\u7ec4\u6210\" class=\"wp-image-15647\" width=\"75\" height=\"75\"\/><\/figure>\n\n\n\n<p><sub>\u8f68\u90531\uff1a\u6df7\u5408\u5bf9\u7167\u54c1\uff0c\u6309\u7167RF\u503c\u9012\u589e\u987a\u5e8f\u4f9d\u6b21\u4e3a DOPS\u3001DOPE\u3001DODMA\u3001\u80c6\u56fa\u9187\uff1b<\/sub><\/p>\n\n\n\n<p><sub>\u8f68\u90532\uff1a\u8102\u8d28\u4f53\u6eb6\u6db2\uff1b<\/sub><\/p>\n\n\n\n<p><sub>\u8f68\u90533\uff1a\u8102\u8d28\u4f53\u5236\u5242\u3002<\/sub><\/p>\n\n\n\n<h2><strong><span class=\"has-inline-color has-vivid-cyan-blue-color\">\u9ad8\u6548\u8584\u5c42\u8272\u8c31\u6280\u672f (HPTLC) \u4f18\u52bf<\/span><\/strong><\/h2>\n\n\n\n<p>\u25cf&nbsp;HPTLC \u5206\u6790<strong>\u5bf9\u6837\u54c1\u524d\u5904\u7406\u8981\u6c42\u4f4e<\/strong>\uff0c<strong>\u8584\u5c42\u677f\u4e00\u6b21\u6027\u4f7f\u7528\u65e0\u6c61\u67d3\u98ce\u9669<\/strong>\uff0c\u5f00\u653e\u5f0f\u8272\u8c31\u53ef\u81ea\u7531\u884d\u751f\u4f7f\u8102\u8d28\u68c0\u6d4b\u53d8\u5f97<strong>\u7b80\u5355\u4e14\u53ef\u89c6\u5316<\/strong>\u3002<\/p>\n\n\n\n<p>\u25cf\u00a0<strong>HPTLC PRO \u5206\u6790 5 \u677f\u7ea6 4.5 \u5c0f\u65f6\uff0c\u5355\u4e2a\u6837\u54c1\u5206\u6790\u5e73\u5747\u8017\u65f6\u7ea6 3.6 \u5206\u949f\u3002<\/strong><\/p>\n\n\n\n<p>\u25cf\u00a0<strong>ADC 2 \u5206\u6790 5 \u677f\u7ea6 7.5 \u5c0f\u65f6\uff0c\u5355\u4e2a\u6837\u54c1\u5206\u6790\u5e73\u5747\u8017\u65f6\u7ea6 6 \u5206\u949f\u3002<\/strong><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-full is-resized\"><img src=\"\/wp-content\/uploads\/2021\/07\/HPTLC-PRO-Full-Series.jpg\" alt=\"HPTLC PRO \u9ad8\u6548\u8584\u5c42\u8272\u8c31\u7cfb\u7edf\u7cfb\u5217\" class=\"wp-image-13370\" width=\"840\" height=\"231\" srcset=\"\/wp-content\/uploads\/2021\/07\/HPTLC-PRO-Full-Series.jpg 1000w, \/wp-content\/uploads\/2021\/07\/HPTLC-PRO-Full-Series-300x83.jpg 300w, \/wp-content\/uploads\/2021\/07\/HPTLC-PRO-Full-Series-768x212.jpg 768w\" sizes=\"(max-width: 840px) 100vw, 840px\" \/><figcaption><sub>CAMAG HPTLC PRO<\/sub><\/figcaption><\/figure><\/div>\n\n\n\n<p>\u4ece\u4ee5\u4e0a\u5206\u6790\uff0c\u5229\u7528 CAMAG \u9996\u521b\u7684 HPTLC PRO \u5168\u81ea\u52a8\u8272\u8c31\u7cfb\u7edf\u66f4\u80fd\u5168\u9762\u63d0\u5347\u6548\u7387\uff0c<strong>\u5b9e\u73b0\u5168\u7a0b\u65e0\u4eba\u5e72\u9884\u7684\u81ea\u52a8\u5316\u8fde\u7eed\u591a\u677f\u4e4b \u201c\u70b9\u6837 \u2013 \u5c55\u5f00 \u2013 \u884d\u751f \u2013 \u68c0\u6d4b \u2013 \u5206\u6790 \u2013 \u62a5\u544a\u201d \u64cd\u4f5c\u6d41\u7a0b<\/strong>\uff0c\u89e3\u51b3\u8272\u8c31\u91cd\u73b0\u6027\u95ee\u9898\u74f6\u9888\uff0c\u5145\u5206\u53d1\u6325 HPTLC \u5feb\u901f\u3001\u76f4\u89c2\u3001\u81ea\u7531\u884d\u751f\u7684\u6280\u672f\u4f18\u52bf\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u590d\u6742\u6210\u5206\u6837\u54c1\u7684\u5206\u79bb\u53ca\u68c0\u6d4b\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator is-style-wide\"\/>\n\n\n\n<h2>\u66f4\u591a\u6587\u7ae0<\/h2>\n\n\n\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column\" style=\"flex-basis:100%\">\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container\">\n<div class=\"wp-block-columns\">\n<div class=\"wp-block-column\" style=\"flex-basis:100%\"><ul class=\"wp-block-latest-posts__list is-grid columns-2 has-dates wp-block-latest-posts\"><li><a href=\"https:\/\/www.nikyang.com\/news\/event-bceia-2023\/\">BCEIA 2023 \u5b8c\u7f8e\u6536\u5b98 | \u529b\u626c\u4f01\u4e1a\u52a9\u60a8\u8fc8\u5411\u667a\u6167\u79d1\u7814\u65b0\u65f6\u4ee3\uff01<\/a><time datetime=\"2023-09-15T12:08:45+08:00\" class=\"wp-block-latest-posts__post-date\">2023-09-15<\/time><\/li>\n<li><a href=\"https:\/\/www.nikyang.com\/news\/event-analytica-china-2023\/\">analytica China \u5706\u6ee1\u843d\u5e55\uff0c\u529b\u626c\u52a9\u529b\u5b9e\u9a8c\u5ba4\u6570\u5b57\u5316\u8f6c\u578b<\/a><time datetime=\"2023-07-14T14:19:23+08:00\" class=\"wp-block-latest-posts__post-date\">2023-07-14<\/time><\/li>\n<li><a href=\"https:\/\/www.nikyang.com\/tlc\/event-announcement-2nd-tcm-conference-training\/\">\u9ad8\u6548\u8584\u5c42\u8272\u8c31\u6280\u672f  \u52a0\u5feb\u4e2d\u836f\u8d28\u91cf\u63a7\u5236\u73b0\u4ee3\u5316<\/a><time datetime=\"2023-06-12T16:16:41+08:00\" class=\"wp-block-latest-posts__post-date\">2023-06-12<\/time><\/li>\n<li><a href=\"https:\/\/www.nikyang.com\/news\/event-biopharm-chromatography2023\/\">\u7b2c\u5341\u56db\u5c4a\u5168\u56fd\u751f\u7269\u533b\u836f\u8272\u8c31\u8d28\u8c31\u53ca\u76f8\u5173\u6280\u672f\u4ea4\u6d41\u4f1a<\/a><time datetime=\"2023-05-19T12:32:56+08:00\" class=\"wp-block-latest-posts__post-date\">2023-05-19<\/time><\/li>\n<\/ul>\n\n\n<p><\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u4eba\u7c7b\u8fce\u6218\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u80ba\u708e (Corona Virus Disease 2019, COVID-19) \u75ab\u60c5\u4e2d\uff0cmRNA \u75ab\u82d7\u7684\u4f5c\u7528\u6bcb\u5eb8\u7f6e\u7591\uff0c\u5b83\u6709\u6548\u9884\u9632\u548c\u63a7\u5236\u4e86\u75c5\u6bd2\u4f20\u64ad\u3002 mRNA \u75ab\u82d7\u5177\u6709\u7814\u53d1\u5468\u671f\u77ed\u3001\u514d\u75ab\u539f\u6027\u5f3a\u3001\u5bf9\u75c5\u539f\u4f53\u53d8\u5f02\u53cd\u5e94\u8fc5\u901f\u548c\u6613\u4e8e\u6279\u91cf\u751f\u4ea7\u7b49\u8bf8\u591a\u4f18\u70b9\u3002\u4f46\u5728\u7814\u53d1\u8fc7\u7a0b\u4e2d\uff0c\u5b83\u4e5f\u5b58\u5728\u7740\u4e1a\u5185\u4f17\u6240\u5468\u77e5\u7684\u4e24\u5927\u6280\u672f\u96be\u70b9\uff1a\u4e00\u662f\u5206\u5b50\u8bbe\u8ba1\uff0c\u4e8c\u662f\u9012\u9001\u7cfb\u7edf\u3002 \u76ee\u524d\u666e\u904d\u91c7\u7528\u8102\u8d28\u7eb3\u7c73\u7c92 (LNP) \u5c01\u88c5 mRNA \u75ab\u82d7\u7684\u8106\u5f31\u5206\u5b50\u3002LNP \u5c01\u88c5\u9012\u9001\u9776\u5411\u6027\u5f3a\u3001\u5305\u5c01\u7387\u9ad8\u3001\u7ec6\u80de\u4eb2\u548c\u6027\u597d\uff0c\u53ef\u4ee5\u9632\u6b62 mRNA \u75ab\u82d7\u7684\u8106\u5f31\u5206\u5b50\u5728\u5230\u8fbe\u4f5c\u7528\u9776\u6807\u4e4b\u524d\u88ab\u6d88\u5316\u6216\u5207\u788e\u3002 \u203b \u672c\u6587\u6240\u5c55\u793a\u7684\u6848\u4f8b\u662f\u901a\u8fc7\u9ad8\u6548\u8584\u5c42\u8272\u8c31\u6280\u672f (HPTLC)\uff0c\u5bf9\u8102\u8d28\u5236\u5242\u914d\u65b9\u7ec4\u6210\u8fdb\u884c\u5feb\u901f\u3001\u7b80\u4fbf\u548c\u7a33\u5065\u7684\u9ad8\u901a\u91cf\u5206\u6790\u68c0\u6d4b\uff0c\u53ef\u5e7f\u6cdb\u5e94\u7528\u4e8e\u8102\u8d28\u5236\u5242\u7684\u914d\u65b9\u7b5b\u9009\u4ee5\u53ca\u8d28\u91cf\u63a7\u5236\u7b49\u7814\u7a76\u3002 mRNA \u75ab\u82d7\u5236\u5242\u4e2d\u8102\u8d28\u6210\u5206\u7684\u5206\u6790 \u9633\u79bb\u5b50\u8102\u8d28\u4f53\u53ef\u4e0e mRNA \u5f62\u6210\u590d\u5408\u7269\uff0c\u4ece\u800c\u6709\u6548\u8fdb\u5165\u7ec6\u80de\u8fdb\u884c\u8f6c\u67d3\u3002\u901a\u5e38\u7684\u9633\u79bb\u5b50\u8102\u8d28\u4f53\u5904\u65b9\u4e2d\u9700\u542b\u6709\u9633\u79bb\u5b50\u8102\u8d28\u3001\u80c6\u56fa\u9187\u3001\u4e2d\u6027\u52a9\u78f7\u8102\u4ee5\u53ca PEG \u5316\u78f7\u8102\u7b49\u3002 \u6848\u4f8b\u4e2d\u9009\u62e9\u4e86 DOPS\u3001DOPE\u3001DOTAP \u7b49\u5e38\u7528\u7684\u8f85\u52a9\u8102\u8d28\u548c\u9633\u79bb\u5b50\u8102\u8d28\u4f5c\u4e3a\u5bf9\u7167\u54c1\uff0c\u6765\u5206\u6790\u68c0\u6d4b\u8102\u8d28\u5236\u5242\u914d\u65b9\u7684\u6210\u5206\u7ec4\u6210\u3002 \u4ee5 mRNA \u75ab\u82d7\u5236\u5242\u4e2d\u8102\u8d28\u6210\u5206\u7684\u5206\u6790\u4e3a\u4f8b\uff0cHPTLC \u5206\u6790\u8272\u8c31\u56fe\u7ed3\u679c\u5982\u4e0b\u6240\u793a\uff1a \u6ce8\uff1a\u6837\u54c1\u4ece\u5de6\u81f3\u53f3\u4f9d\u6b21\u4e3a DOPS (\u4e8c\u6cb9\u9170\u57fa\u78f7\u8102\u9170\u4e1d\u6c28\u9178)\uff0clyso-DOPE (\u6eb6\u8840-\u4e8c\u6cb9\u9170\u78f7\u8102\u9170\u4e59\u9187\u80fa)\uff0cDOTAP (\u6eb4\u5316\u4e09\u7532\u57fa-2, 3-\u4e8c\u6cb9\u9170\u6c27\u57fa\u4e19\u57fa\u94f5)\uff0cDOPE (\u4e8c\u6cb9\u9170\u78f7\u8102\u9170\u4e59\u9187\u80fa)\uff0cDOTMA (\u6c2f\u5316\u4e09\u7532\u57fa-2, 3-\u4e8c\u6cb9\u70ef\u6c27\u57fa\u4e19\u57fa\u94f5)\uff0cDODMA (1,2-\u4e8c\u6cb9\u9187-3-\u4e8c\u7532\u57fa\u6c28\u57fa-\u4e19\u70f7)\uff0c\u6cb9\u9178\uff0c\u80c6\u56fa\u9187 \u5e94\u7528\u4e0a\u8ff0\u8272\u8c31\u6761\u4ef6\u5bf9\u672a\u77e5\u7ec4\u6210\u7684\u5236\u5242\u6837\u54c1\u8fdb\u884c HPTLC \u5206\u79bb\uff0c\u53ef\u6839\u636e\u8272\u8c31\u7ed3\u679c\u63a8\u6d4b\u5236\u5242\u914d\u65b9\u7ec4\u6210\u3002 \u8f68\u90531\uff1a\u6df7\u5408\u5bf9\u7167\u54c1\uff0c\u6309\u7167RF\u503c\u9012\u589e\u987a\u5e8f\u4f9d\u6b21\u4e3a DOPS\u3001DOPE\u3001DODMA\u3001\u80c6\u56fa\u9187\uff1b \u8f68\u90532\uff1a\u8102\u8d28\u4f53\u6eb6\u6db2\uff1b \u8f68\u90533\uff1a\u8102\u8d28\u4f53\u5236\u5242\u3002 \u9ad8\u6548\u8584\u5c42\u8272\u8c31\u6280\u672f (HPTLC) \u4f18\u52bf 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