{"id":1464,"date":"2018-09-18T17:10:05","date_gmt":"2018-09-18T09:10:05","guid":{"rendered":"http:\/\/www.nikyang.com\/?p=1464"},"modified":"2021-08-25T12:19:33","modified_gmt":"2021-08-25T04:19:33","slug":"rapid-screening-for-breast-cancer","status":"publish","type":"post","link":"https:\/\/www.nikyang.com\/bio-sample-prep\/rapid-screening-for-breast-cancer\/","title":{"rendered":"\u3010DBS\u65b0\u5e94\u7528\u3011\u4e73\u817a\u764c\u5feb\u901f\u7b5b\u67e5"},"content":{"rendered":"<p><strong>\u4e73\u817a\u764c\uff08Breast Cancer, BC\uff09<\/strong>\u5bf9\u4e16\u754c\u5404\u5730\u7684\u5987\u5973\u4ecd\u7136\u662f\u81f4\u547d\u7684\u5a01\u80c1\u3002<\/p>\n<p>\u5728\u8fd9\u533b\u5b66\u53d1\u8fbe\u7684\u65f6\u4ee3\uff0c<strong>\u5e72\u8840\u6591 (Dried Blood Spot, DBS) \u6280\u672f<\/strong>\u4e5f\u53ef\u4ee5\u4e3a\u4e73\u817a\u764c\u7b5b\u67e5\u5de5\u4f5c\u63d0\u4f9b\u7b80\u5355\u3001\u4fbf\u6377\u7684\u65b9\u6848\u3002\u4ece\u4e34\u5e8a\u89d2\u5ea6\u6765\u770b\uff0c\u5e72\u8840\u6591\u6280\u672f\u4ee5\u6613\u4e8e\u64cd\u4f5c\u7684\u65b9\u5f0f\u8fdb\u884c\u51c6\u786e\u7684\u7b5b\u67e5\u548c\u8bca\u65ad\u7b56\u7565\u662f\u975e\u5e38\u6709\u4fdd\u8bc1\u7684\u3002\u9664\u4e86\u5e38\u89c4\u91c7\u7528\u7684\u86cb\u767d\u8d28\u6807\u5fd7\u7269\u4e4b\u5916\uff0c\u8840\u6db2\u4e2d\u8fd8\u542b\u6709\u5177\u6709\u4e0d\u540c\u7ed3\u6784\u548c\u6027\u8d28\u7684\u5c0f\u5206\u5b50\u4ee3\u8c22\u7269\u3002<\/p>\n<p>\u4e00\u73ed\u4e2d\u56fd\u5b66\u8005 2016 \u5e74\u5728OncoTargets and Therapy\u6742\u5fd7\u4e0a\u53d1\u8868\u7684\u7814\u7a76\uff0c<strong>\u91c7\u7528 DBS \u00a0\u8054\u7528\u8d28\u8c31 (MS) \u8fdb\u884c\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\uff0c<\/strong>\u5bf9\u4e73\u817a\u764c\u60a3\u8005\u548c\u975e\u4e73\u817a\u764c\u60a3\u8005\u8fdb\u884c\u7b5b\u67e5\uff0c\u7b5b\u9009\u4e86\u5177\u6709\u4e73\u817a\u764c\u8bca\u65ad\u6f5c\u529b\u7684\u4ee3\u8c22\u7269\u6807\u5fd7\u7269\u3002\u7814\u7a76\u4e2d\uff0c\u76ee\u6807\u5206\u6790\u7269\u5305\u62ec 23 \u4e2a\u6c28\u57fa\u9178\u548c 26 \u4e2a\u9170\u57fa\u8089\u78b1\u3002<\/p>\n<section>\n<section>\u4e3a\u4f55\u8003\u8651\u91c7\u7528 DBS \u5e72\u8840\u6591\u65b9\u6cd5\uff1f<\/section>\n<\/section>\n<div class=\"qb_sc_image_container\"><img class=\"alignnone wp-image-1532 size-full\" src=\"\/wp-content\/uploads\/2018\/09\/sszz-2.jpg\" alt=\"\" width=\"500\" height=\"305\" srcset=\"\/wp-content\/uploads\/2018\/09\/sszz-2.jpg 500w, \/wp-content\/uploads\/2018\/09\/sszz-2-300x183.jpg 300w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/div>\n<p>\u8be5\u7814\u7a76\u63d0\u5230\uff0c\u7531\u4e8e<strong>\u57fa\u4e8e DBS \u7684 MS \u5206\u6790\u6280\u672f<\/strong>\u53ef\u7528\u4e8e\u65b0\u751f\u513f\u4ee3\u8c22\u75c5\u7b5b\u67e5 \uff0c\u800c\u4e14\u5b83\u5df2\u6709\u51e0\u5341\u5e74\u7684\u4f7f\u7528\u5386\u53f2\uff0c\u56e0\u6b64\u5b83\u4e5f\u53ef\u7528\u4e8e\u80bf\u7624\u4ee3\u8c22\u6807\u5fd7\u7269\u7b5b\u9009\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u8fdb\u884c\u57fa\u4e8e DBS \u7684\u4ee3\u8c22\u7ec4\u5b66\u7814\u7a76\uff0c\u91c7\u7528\u76f4\u63a5\u6ce8\u5165\u5f0f\u4e32\u8054\u8d28\u8c31\u6cd5 (direct infusion MS \/ MS) \u00a0\u5206\u6790\u4e73\u817a\u764c\u548c\u5bf9\u7167\u7ec4\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u591a\u53d8\u91cf<strong>\u5206\u6790\u7b5b\u9009\u4e86\u8840\u6db2\u4e2d\u4e0e\u4e73\u817a\u764c\u76f8\u5173\u768421\u79cd\u4ee3\u8c22\u7269\u3002<\/strong>\u56de\u5f52\u5206\u6790\u4ea7\u751f\u4e86\u7531 Pip\u3001Asn\u3001Pro\u3001C14\uff1a1\/C16\u3001Phe \/ Tyr \u548c Gly \/ Ala \u7ec4\u6210\u7684\u8bca\u65ad\u6a21\u578b\u3002\u7528\u4e73\u817a\u764c\u548c\u975e\u4e73\u817a\u764c\u6837\u54c1\u8fdb\u884c\u6d4b\u8bd5\uff0c\u8be5\u6a21\u578b\u663e\u793a\u51fa92.2% \u7684\u654f\u611f\u6027\u548c84.4% \u7684\u7279\u5f02\u6027\u3002\u4e0e\u5e38\u89c4\u4f7f\u7528\u7684\u86cb\u767d\u8d28\u6807\u5fd7\u7269\u76f8\u6bd4\uff0c\u8be5\u6a21\u578b\u5177\u6709\u8f83\u9ad8\u7684\u7075\u654f\u5ea6\u7684\u663e\u7740\u4f18\u52bf\u3002<\/p>\n<p><strong>DBS \u8840\u6db2\u4ee3\u8c22\u7269\u7b5b\u67e5<\/strong>\u662f\u4e73\u817a\u764c\u68c0\u6d4b\u66f4\u5408\u7406\u7684\u65b9\u6cd5\u3002\u6b64\u5916\uff0c\u76f4\u63a5\u5f0f\u8d28\u8c31 MS \u5206\u6790\u53ef\u4ee5\u5728\u51e0\u5206\u949f\u5185\u5b8c\u6210\uff0c\u8fd9\u610f\u5473\u7740\u8be5\u65b9\u6cd5\u7684\u901a\u91cf\u9ad8\u4e8e\u76ee\u524d\u91c7\u7528\u7684\u533b\u5b66\u6210\u50cf\u6280\u672f\u3002<\/p>\n<p>\u5728\u4eca\u5929\uff0c\u663e\u800c\u6613\u89c1\uff0c<strong>DBS\u6280\u672f<\/strong>\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e73\u817a\u764c\u7b5b\u67e5\u5de5\u4f5c\u53ef\u65b9\u4fbf\u7528\u6237\u968f\u65f6\u505a\u4e34\u5e8a\u7b5b\u68c0\uff0c\u60f3\u4f53\u9a8c DBS\u8fd9\u79cd\u65b0\u6280\u672f\u5417\uff1f\u9a6c\u4e0a\u4e0e\u6211\u4eec\u8054\u7cfb\u3002<\/p>\n<section>\n<section><strong>\u53c2\u8003\u6587\u732e\uff1a<\/strong>Reference: \u00a0Wang Q, Sun\u00a0T, et al.\u00a0A dried blood spot mass spectrometry metabolomic approach for rapid breast cancer detection.\u00a0Onco Targets Ther. 2016 Mar 11;9:1389-98. doi: 10.2147\/OTT.https:\/\/www.dovepress.com\/a-dried-blood-spot-mass-spectrometry-metabolomic-approach-for-rapid-br-peer-reviewed-article-OTT<\/p>\n<\/section>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>\u4e73\u817a\u764c\uff08Breast Cancer, BC\uff09\u5bf9\u4e16\u754c\u5404\u5730\u7684\u5987\u5973\u4ecd\u7136\u662f\u81f4\u547d\u7684\u5a01\u80c1\u3002 \u5728\u8fd9\u533b\u5b66\u53d1\u8fbe\u7684\u65f6\u4ee3\uff0c\u5e72\u8840\u6591 (Dried Blood Spot, DBS) \u6280\u672f\u4e5f\u53ef\u4ee5\u4e3a\u4e73\u817a\u764c\u7b5b\u67e5\u5de5\u4f5c\u63d0\u4f9b\u7b80\u5355\u3001\u4fbf\u6377\u7684\u65b9\u6848\u3002\u4ece\u4e34\u5e8a\u89d2\u5ea6\u6765\u770b\uff0c\u5e72\u8840\u6591\u6280\u672f\u4ee5\u6613\u4e8e\u64cd\u4f5c\u7684\u65b9\u5f0f\u8fdb\u884c\u51c6\u786e\u7684\u7b5b\u67e5\u548c\u8bca\u65ad\u7b56\u7565\u662f\u975e\u5e38\u6709\u4fdd\u8bc1\u7684\u3002\u9664\u4e86\u5e38\u89c4\u91c7\u7528\u7684\u86cb\u767d\u8d28\u6807\u5fd7\u7269\u4e4b\u5916\uff0c\u8840\u6db2\u4e2d\u8fd8\u542b\u6709\u5177\u6709\u4e0d\u540c\u7ed3\u6784\u548c\u6027\u8d28\u7684\u5c0f\u5206\u5b50\u4ee3\u8c22\u7269\u3002 \u4e00\u73ed\u4e2d\u56fd\u5b66\u8005 2016 \u5e74\u5728OncoTargets and Therapy\u6742\u5fd7\u4e0a\u53d1\u8868\u7684\u7814\u7a76\uff0c\u91c7\u7528 DBS \u00a0\u8054\u7528\u8d28\u8c31 (MS) \u8fdb\u884c\u4ee3\u8c22\u7ec4\u5b66\u5206\u6790\uff0c\u5bf9\u4e73\u817a\u764c\u60a3\u8005\u548c\u975e\u4e73\u817a\u764c\u60a3\u8005\u8fdb\u884c\u7b5b\u67e5\uff0c\u7b5b\u9009\u4e86\u5177\u6709\u4e73\u817a\u764c\u8bca\u65ad\u6f5c\u529b\u7684\u4ee3\u8c22\u7269\u6807\u5fd7\u7269\u3002\u7814\u7a76\u4e2d\uff0c\u76ee\u6807\u5206\u6790\u7269\u5305\u62ec 23 \u4e2a\u6c28\u57fa\u9178\u548c 26 \u4e2a\u9170\u57fa\u8089\u78b1\u3002 \u4e3a\u4f55\u8003\u8651\u91c7\u7528 DBS \u5e72\u8840\u6591\u65b9\u6cd5\uff1f \u8be5\u7814\u7a76\u63d0\u5230\uff0c\u7531\u4e8e\u57fa\u4e8e DBS \u7684 MS \u5206\u6790\u6280\u672f\u53ef\u7528\u4e8e\u65b0\u751f\u513f\u4ee3\u8c22\u75c5\u7b5b\u67e5 \uff0c\u800c\u4e14\u5b83\u5df2\u6709\u51e0\u5341\u5e74\u7684\u4f7f\u7528\u5386\u53f2\uff0c\u56e0\u6b64\u5b83\u4e5f\u53ef\u7528\u4e8e\u80bf\u7624\u4ee3\u8c22\u6807\u5fd7\u7269\u7b5b\u9009\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u8fdb\u884c\u57fa\u4e8e DBS \u7684\u4ee3\u8c22\u7ec4\u5b66\u7814\u7a76\uff0c\u91c7\u7528\u76f4\u63a5\u6ce8\u5165\u5f0f\u4e32\u8054\u8d28\u8c31\u6cd5 (direct infusion MS \/ MS) \u00a0\u5206\u6790\u4e73\u817a\u764c\u548c\u5bf9\u7167\u7ec4\u3002 \u8be5\u7814\u7a76\u591a\u53d8\u91cf\u5206\u6790\u7b5b\u9009\u4e86\u8840\u6db2\u4e2d\u4e0e\u4e73\u817a\u764c\u76f8\u5173\u768421\u79cd\u4ee3\u8c22\u7269\u3002\u56de\u5f52\u5206\u6790\u4ea7\u751f\u4e86\u7531 Pip\u3001Asn\u3001Pro\u3001C14\uff1a1\/C16\u3001Phe \/ Tyr \u548c Gly \/ Ala \u7ec4\u6210\u7684\u8bca\u65ad\u6a21\u578b\u3002\u7528\u4e73\u817a\u764c\u548c\u975e\u4e73\u817a\u764c\u6837\u54c1\u8fdb\u884c\u6d4b\u8bd5\uff0c\u8be5\u6a21\u578b\u663e\u793a\u51fa92.2% \u7684\u654f\u611f\u6027\u548c84.4% \u7684\u7279\u5f02\u6027\u3002\u4e0e\u5e38\u89c4\u4f7f\u7528\u7684\u86cb\u767d\u8d28\u6807\u5fd7\u7269\u76f8\u6bd4\uff0c\u8be5\u6a21\u578b\u5177\u6709\u8f83\u9ad8\u7684\u7075\u654f\u5ea6\u7684\u663e\u7740\u4f18\u52bf\u3002 DBS \u8840\u6db2\u4ee3\u8c22\u7269\u7b5b\u67e5\u662f\u4e73\u817a\u764c\u68c0\u6d4b\u66f4\u5408\u7406\u7684\u65b9\u6cd5\u3002\u6b64\u5916\uff0c\u76f4\u63a5\u5f0f\u8d28\u8c31 MS \u5206\u6790\u53ef\u4ee5\u5728\u51e0\u5206\u949f\u5185\u5b8c\u6210\uff0c\u8fd9\u610f\u5473\u7740\u8be5\u65b9\u6cd5\u7684\u901a\u91cf\u9ad8\u4e8e\u76ee\u524d\u91c7\u7528\u7684\u533b\u5b66\u6210\u50cf\u6280\u672f\u3002 \u5728\u4eca\u5929\uff0c\u663e\u800c\u6613\u89c1\uff0cDBS\u6280\u672f\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e73\u817a\u764c\u7b5b\u67e5\u5de5\u4f5c\u53ef\u65b9\u4fbf\u7528\u6237\u968f\u65f6\u505a\u4e34\u5e8a\u7b5b\u68c0\uff0c\u60f3\u4f53\u9a8c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1532,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[186],"tags":[97,131],"_links":{"self":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts\/1464"}],"collection":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/comments?post=1464"}],"version-history":[{"count":3,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts\/1464\/revisions"}],"predecessor-version":[{"id":3532,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/posts\/1464\/revisions\/3532"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/media\/1532"}],"wp:attachment":[{"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/media?parent=1464"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/categories?post=1464"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.nikyang.com\/wp-json\/wp\/v2\/tags?post=1464"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}