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Software-driven robotic platform for parallel synthesis workflows
Modular robotic platform for automated synthesis
Chemspeed's Synthesizer SLTII is a modular robotic platform enabling automated synthesis on a single platform under virtually any conditions. The versatility of the Synthesizer Platform allows full automation of complete workflows including reagent preparation (liquids and solids), multistep synthesis, workup, purification, analysis and product transfer to storage. It combines fully automated and unattended synthesis with innovative chemical handling techniques capable of dispensing solids as conveniently and accurately as liquids.
It is suitable for challenging parallel synthesis workflows in the pharmaceutical, agrochemical, fine and specialty chemicals, polymer and catalyst, material science, organic chemistry, biochemistry and other industries.
- Easy-to-use workflow task-driven software
- Wide selection of exchangeable robotic tools, interchangeable with other Chemspeed platforms
- Unrivalled overhead gravimetric dispensing/dosing technology
- Unique reactor block and reactor array technology – can hold up to 12 Chemspeed reactor blocks carrying up to 192 reaction vessels for virtually all kinds of chemistry-related applications
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- A large choice of hardware and software tools allows fine-tuned adaptation to your workflow
- Ability to dispense virtually any type of compound into any type of container (vial, microtiter plates, bottles, reactors, formulation vessels etc.)
- Large choice of reactors with volume from 2 to 100 ml: glass (disposable) or stainless steel; for liquid and solid phase synthesis; also for ambient and elevated pressure (up to 100 bar)
- Efficient yet gentle vortex mixing (up to 1,400 rpm), even while accessing the reactor
- Inert atmosphere for sensitive reagents / inert reaction conditions / low-temperature chemistry
- Automated work-up and analysis: vacuum, filtration, evaporation, liquid/liquid extraction, SPE purification, crystallization, Dean Stark, TLC, interface to analytical devices, etc.
- Access to reactors while heating, cooling and shaking
- Broad temperature range (-70 to +180oC, measured and controlled in a reference reactor)
- Library synthesis
- Reaction parameter screening
- Polymorph screening
- Solubility, stability, compatibility screening
- Catalyst preparation and testing
- Sample preparation
- Formulation screening
- Assessment of the Reusability of Pd Complexes Supported on Fluorous Silica Gel as Catalysts for Suzuki Couplings
- Automated reaction optimisation of the enantioselective alpha-arylation of aldehydes via SOMO catalysis
- Automated Sample Preparation in Analytical Chemistry
- Automated Synthesis of Dendritic Core-Shell Architectures with Click Chemistry
- Automated Synthesis of Methacrylate (MA) Polymers using RAFT
- Parameter Screening in Process Development – Ligand-free Heck Reactions
- Speeding-up the Process from Substance Discovery to Commercialization
- The Influence of Vortex Agitation on Biphasic Phase Transfer Catalyzed Reactions Carbene Addition